近红外光声成像引导的靶向抗癌联合疗法——以靶向肿瘤的铜硒化铁锰层状双氢氧化物纳米复合物为基础。
NIR-II photoacoustic imaging-guided synergistic cancer therapy with a tumor-targeting copper selenide-iron manganese layered double hydroxide nanocomplex.
发表日期：2023 Sep 04
作者：
Yanting Yang, Shulong Wang, Shengqiang Hu, Yanni Luo, Zongyi He, Shulin Zhao
来源：
MOLECULAR & CELLULAR PROTEOMICS
摘要：
本研究制备了一种新型的可降解层状双氢氧化物-铜硒化物纳米复合物，通过将铜硒化物固定在锰铁层状双氢氧化物纳米片上。在肿瘤微环境中，该纳米复合物可以特异性释放CuSe、Mn2+和Fe3+，并在1064 nm激光照射下实现NIR-II光声成像引导的协同抗癌治疗。
A novel biodegradable layered double hydroxide-copper selenide nanocomplex was prepared by anchoring copper selenide on manganese iron layered double hydroxide nanosheets. This nanocomplex can specifically release CuSe, Mn2+ and Fe3+ in the tumor microenvironment, which implements NIR-II photoacoustic imaging-guided synergistic cancer therapy under 1064 nm laser irradiation.