结直肠癌是全球严重的健康问题，可通过改变饮食生活方式进行治疗。它在结肠上皮细胞的炎症介导下形成，经历无控制的细胞分裂和增殖。细菌酶释放肠道微生物代谢产物导致结直肠癌的大规模爆发。病原体相关分子模式和损伤相关分子模式激活NLPR3炎症体通路，释放促炎细胞因子以诱导结直肠癌。另外，特定的趋化因子和受体复合物与细胞增殖和转移有关。细菌酶协同攻击结肠粘膜，导致细胞完整性退化和溶酶体溢出。这些因素进一步激活Toll样受体（TLR）和Nod样受体（NLR），促进血管生成并为癌细胞供应营养物质。肉桂醇是一种单萜化合物，近年来越来越受重视，广泛用于抗癌、神经退行性疾病和糖尿病等多种疾病的治疗。根据研究数据，该综述着重介绍了肉桂醇的抗癌特性，强调其治疗性能，能够抑制炎症体通路和其他信号通路。组合治疗因能针对细胞应激状态下的所有变异而受到重视。以肉桂醇和其它单萜化合物进行的临床研究显示出积极的结果，可能开启一种有效的抗癌药物治疗方法。本综述突出了肉桂醇及其作为一种经济有效的预防和治疗结直肠癌药物的生物活性。© 2023 Wiley Periodicals LLC.

Colon cancer is a serious health problem across the globe with various dietary lifestyle modifications. It arises as an inflammation mediated crypts in the colon epithelial cells and undergoes uncontrolled cell division and proliferation. Bacterial enzymes contribute to a major outbreak in colon cancer development upon the release of toxic metabolites from the gut microflora. Pathogen associated molecular patterns and damage associated molecular patterns triggers the NLPR3 inflammasome pathways that releases pro-inflammatory cytokines to induce cancer of the colon. Contributing to this, specific chemokines and receptor complexes attribute to cellular proliferation and metastasis. Bacterial enzymes synergistically attack the colon mucosa and degenerate the cellular integrity causing lysosomal discharge. These factors further instigate the Tol like receptors (TLRs) and Nod like receptors (NLRs) to promote angiogenesis and supply nutrients for the cancer cells. Myrtenal, a monoterpene, is gaining more importance in recent times and it is being widely utilized against many diseases such as cancers, neurodegenerative diseases and diabetes. Based on the research data's, the reviews focus on the anticancer property of myrtenal by emphasizing its therapeutic properties which downregulate the inflammasome pathways and other signalling pathways. Combination therapy is gaining more importance as they can target every variant in the cellular stress condition. Clinical studies with compounds like myrtenal of the monoterpenes family is provided with positive results which might open an effective anticancer drug therapy. This review highlights myrtenal and its biological potency as a cost effective drug for prevention and treatment of colon cancer.© 2023 Wiley Periodicals LLC.