铁死（Ferroptosis）是一种近期认知到的具有形态学、生物化学和分子机制方面显著特征的细胞死亡形式。不同于其他类型的细胞死亡，铁死以铁依赖性、活性氧积累和脂质过氧化物为特征。最近的研究表明选择性自噬在诱导铁死中起着重要作用，包括铁蛋白自噬、脂类自噬、时钟自噬和伴侣蛋白介导的自噬。新兴的证据表明铁死通过调节肿瘤生长、转移、干细胞性、药物抵抗和复发等多种生物过程参与了肿瘤发生。临床和临床前研究发现，针对铁死的新型治疗在肿瘤治疗中具有巨大潜力。本综述全面介绍了铁死的分子机制，尤其是自噬驱动的铁死，并讨论了铁死在肿瘤发生中的生物学作用的最新进展，并强调了新型针对铁死的治疗在临床肿瘤治疗中的应用。 版权所有 © 2023 作者。由Elsevier Masson SAS出版。版权所有。

Ferroptosis is a recently recognized form of cell death with distinct features in terms of morphology, biochemistry, and molecular mechanisms. Unlike other types of cell death, ferroptosis is characterized by iron dependence, reactive oxygen species accumulation and lipid peroxidation. Recent studies have demonstrated that selective autophagy plays a vital role in the induction of ferroptosis, including ferritinophagy, lipophagy, clockophagy, and chaperone-mediated autophagy. Emerging evidence has indicated the involvement of ferroptosis in tumorigenesis through regulating various biological processes, including tumor growth, metastasis, stemness, drug resistance, and recurrence. Clinical and preclinical studies have found that novel therapies targeting ferroptosis exert great potential in the treatment of tumors. This review provides a comprehensive overview of the molecular mechanisms in ferroptosis, especially in autophagy-driven ferroptosis, discusses the recent advances in the biological roles of ferroptosis in tumorigenesis, and highlights the application of novel ferroptosis-targeted therapies in the clinical treatment of tumors.Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.