骨肿瘤切除术后，癌症复发风险和多发骨缺损持续威胁患者健康。为了克服这一挑战，我们开发了一种新型多功能支架材料，主要由纳米羟基磷灰石颗粒（n-HA）、MXene纳米片和g-C3N4组成，以防止肿瘤复发并促进骨再生。N-HA具有限制骨肉瘤细胞生长的潜力，而MXene和g-C3N4的组合使支架能够在近红外（NIR）照射下同时产生光动力和光热效应。令人惊讶的是，n-HA可以进一步增强光动力和光热协同抗肿瘤功能，支架可以在仅10分钟内以45℃的温度迅速根除骨肉瘤细胞。此外，支架具有优异的细胞相容性，并且具有诱导骨髓间充质干细胞成骨分化的能力。因此，这种多功能支架不仅可以抑制骨肿瘤细胞的增殖并通过近红外照射迅速根除骨肉瘤，还可以增强成骨活性。这一有前景的措施可用于骨肿瘤切除后的组织损伤治疗。版权所有 © 2023 Elsevier Inc. 保留所有权利。

After resection of bone tumour, the risk of cancer recurrence and numerous bone defects continues to threaten the health of patients. To overcome the challenge, we developed a novel multifunctional scaffold material consisting mainly of nano-hydroxyapatite particles (n-HA), MXene nanosheets and g-C3N4 to prevent tumour recurrence and promote bone formation. N-HA has the potential to restrict the growth of osteosarcoma cells, and the combination of MXene and g-C3N4 enables the scaffolds to produce photodynamic and photothermal effects simultaneously under near infrared (NIR) irradiation. Surprisingly, n-HA can further enhance the synergistic anti-tumour function of photodynamic and photothermal, and the scaffolds can eradicate osteosarcoma cells in only 10 min at a mild temperature of 45 ℃. Moreover, the scaffold exhibit exceptional cytocompatibility and possesses the capacity to induce osteogenic differentiation of bone marrow mesenchymal stem cells. Therefore, this multifunctional scaffold can not only inhibits the proliferation of bone tumour cells and rapidly eradicate bone tumour through NIR irradiation, but also enhances osteogenic activity. This promising measure can be used to treat tissue damage after bone tumour resection.Copyright © 2023 Elsevier Inc. All rights reserved.