心血管（CV）和肿瘤疾病的全球负担持续增加。在这方面，心血管疾病（CVD）在癌症治疗前后的预防是医学中一个紧迫且尚未解决的问题。因此，我们的研究小组旨在使用慢性阿霉素（A）+环磷酰胺（C）化疗诱导心肌病的实验模型，探讨达格列凡相关的心脏保护可能性。通过测量氧化还原平衡、脂质代谢、内皮功能紊乱和心肌损伤指标，评估达格列凡诱导CV稳态稳定的途径。为了进行这项研究，我们随机分配了80只纯系维斯塔大鼠到四个大小相等的组。通过使用阿霉素和环磷酰胺联合给药来建立慢性心毒性模型。在这种情况下，评估了氧化还原平衡、胆固醇代谢、内皮功能紊乱、心肌变化和形态学检查的标志物。对于所有参数，都获得了具有统计学意义的偏差，强调了AC模式化疗相关的洗涤剂效应对心血管系统（第2组）的影响。此外，达格列凡治疗组（第3组）获得的数据表明，该策略可以限制脂质过氧化、胆固醇代谢和内皮功能的正常化，并随后形态学保护心肌。达格列凡具有广泛的多向影响，包括降低胆固醇、抗炎和稳定内皮细胞的特性。这些特性为防止化疗相关的心肌病提供了有利的环境。版权所有 © 2023. Elsevier B.V. 发布。

The global burden of cardiovascular (CV) and oncological diseases continues to increase. In this regard, the prevention of CV diseases (CVD) before and after cancer treatment is an urgent and unsolved problem in medicine. For this reason, our research group aimed to investigate the possibility of dapagliflozin-related cardioprotection, using an experimental model of chronic Doxorubicin (Adriamycin) + Cyclophosphamide (AC)-mode of chemotherapy-induced cardiomyopathy.The redox balance, lipid metabolism, endothelial dysfunction, and myocardial damage parameters were measured to evaluate the pathways of dapagliflozin-induced stabilization of CV homeostasis.For this study, 80 inbred Wistar rats were randomly assigned to four equally sized groups. A model of chronic cardiotoxicity was attained by using doxorubicin and cyclophosphamide co-administration. In the case, the markers of redox-balance, cholesterol metabolism, endothelial dysfunction, myocardial alteration, and morphological examination were assessed.For all parameters, statistically significant deviations were obtained, emphasizing the sequel of AC-mode chemotherapy-related detergent effect on CV system (group 2). Moreover, the data obtained from dapagliflozin-treated groups (group 3) showed that this strategy provide limitation of lipid peroxidation, cholesterol metabolism and endothelial function normalization, with subsequent morphological preservation of myocardium.Dapagliflozin has a broad spectrum of pleiotropic influences, namely cholesterol-lowering, anti-inflammatory, and endothelium-stabilizing properties. These properties provide a favorable environment for the prevention of chemotherapy-related cardiomyopathy.Copyright © 2023. Published by Elsevier B.V.