转移是肿瘤的一个主要标志，其重要性不仅与基础研究有关，而且临床研究表明，大多数癌症死亡是由转移引起的。肿瘤细胞的转移在于EMT机制的显著增加，因此，抑制EMT可以降低肿瘤细胞的生物学行为，提高患者的生存率。与癌症转移相关的一个差距是缺乏对某些类型的肿瘤细胞中EMT调控的特定关注。胃癌和膀胱癌被认为是临床层面上导致患者死亡的两个主要原因。在此，评估了EMT在它们进展调控中的作用，以miRNA的功能为重点。讨论了这些癌症中对EMT的抑制/诱导以及它们在调节EMT相关因子包括ZEB1/2蛋白、TGF-β、蛇形蛋白和细胞间粘附蛋白的能力。此外，还讨论了lncRNA和circRNA在这些肿瘤中miRNA/EMT调控交流中的作用，并评估了对癌症转移和肿瘤细胞对化疗的响应的最终影响。此外，还讨论了通过胞外体传递的miRNA在调控这些癌症中的EMT中的作用。版权所有 © 2023 Elsevier Inc.

The metastasis a major hallmark of tumors that its significant is not only related to the basic research, but clinical investigations have revealed that majority of cancer deaths are due to the metastasis. The metastasis of tumor cells is significantly increased due to EMT mechanism and therefore, inhibition of EMT can reduce biological behaviors of tumor cells and improve the survival rate of patients. One of the gaps related to cancer metastasis is lack of specific focus on the EMT regulation in certain types of tumor cells. The gastric and bladder cancers are considered as two main reasons of death among patients in clinical level. Herein, the role of EMT in regulation of their progression is evaluated with a focus on the function of miRNAs. The inhibition/induction of EMT in these cancers and their ability in modulation of EMT-related factors including ZEB1/2 proteins, TGF-β, Snail and cadherin proteins are discussed. Moreover, lncRNAs and circRNAs in crosstalk of miRNA/EMT regulation in these tumors are discussed and final impact on cancer metastasis and response of tumor cells to the chemotherapy is evaluated. Moreover, the impact of miRNAs transferred by exosomes in regulation of EMT in these cancers are discussed.Copyright © 2023. Published by Elsevier Inc.