转移性癌症的扩散导致了大多数癌症相关死亡。在继发器官中种植癌细胞需要对局部间质和免疫环境进行重编程，最终支持肿瘤生长。然而，促进这种肿瘤有利环境的细胞和分子机制仍然大部分未知。近期研究表明，先天淋巴细胞（ILCs）以多种方式调节癌症的免疫反应。作为组织驻留性细胞，ILCs能够对早期或预转移生态位中的局部信号作出反应，并组织额外免疫细胞的招募，这些细胞可能支持或抑制转移性生长。在本综述中，我们回顾了新出现的证据，支持ILCs在转移的建立和进展中发挥作用，同时讨论了不同ILC亚群所归因于的多效作用。版权©2023。由Elsevier Ltd.出版。

Metastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogramming of the local stromal and immune landscape, which ultimately supports tumour growth. Yet, the cellular and molecular mechanisms that promote this tumour-permissive environment remain largely unknown. Innate lymphoid cells (ILCs) have recently been shown to modulate the immune response to cancer in multiple ways. Given their tissue-resident nature, ILCs are well placed to respond to local cues within the early or pre-metastatic niche, and to orchestrate the recruitment of additional immune cells that could either support or dampen metastatic growth. Here, we review the emerging body of evidence supporting a role for ILCs in the establishment and progression of metastasis, whilst discussing the pleiotropic effects that have been attributed to different ILC subsets.Copyright © 2023. Published by Elsevier Ltd.