前列腺癌（PCa）是男性最常见的癌症（20%），并负责全球男性癌症相关死亡的6.8%（1/5）。前列腺癌的发展和传播受到广泛的基因组变化和广泛的表观遗传事件的驱动。因此，直到今天，在前列腺癌的起源和侵袭性中仅部分鉴定了微小RNA（miRNA）及其相关的分子机制。miRNA是一类新发现的调节因子，最近被认为在调控癌症机制的许多要素中起着重要作用，如增殖、分化、代谢和凋亡。miRNA是一类小（22-24核苷酸），非编码的内源性单链RNA，作为强大的基因调控因子发挥作用。包括前列腺癌在内的各种类型的癌症发现，miRNA基因通常位于与癌症相关的基因区域或易损位置，它们在肿瘤发生的初步阶段起着促癌基因或抑癌基因的角色。为了解释miRNA与前列腺癌的起始和发展之间的联系，我们进行了初步评估。本研究的目的是通过阐明miRNA表达谱和前列腺癌之间的基本过程及靶基因来提高我们对miRNA表达与前列腺癌之间关联的理解。版权所有©2023 Elsevier B.V. 保留所有权利。

Prostate cancer (PCa) is the most common cancer in men (20%) and is responsible for 6.8% (1/5) of all cancer-related deaths in men around the world. The development and spread of prostate cancer are driven by a wide variety of genomic changes and extensive epigenetic events. Because of this, the MicroRNA (miRNA) and associated molecular mechanisms involved in PCa genesis and aggressive were only partially identified until today. The miRNAs are a newly discovered category of regulatorsthat have recently been recognized to have a significant role in regulating numerous elements of cancer mechanisms, such as proliferation, differentiation, metabolism, and apoptosis. The miRNAs are a type of small (22-24 nucleotides), non-coding, endogenous, single-stranded RNA and work as potent gene regulators. Various types of cancer, including PCa, have found evidence that miRNA genes, which are often located in cancer-related genetic regions or fragile locations, have a role in the primary steps of tumorigenesis, either as oncogenes or tumorsuppressors. To explain the link between miRNAs and their function in the initiation and advancement of PCa, we conducted a preliminary assessment. The purpose of this research was to enhance our understanding of the connection between miRNA expression profiles and PCa by elucidating the fundamental processes of miRNA expression and the target genes.Copyright © 2023 Elsevier B.V. All rights reserved.