高风险人类乳头状瘤病毒（HR-HPV）感染是全球感染相关癌症的主要原因。对3,101例HR-HPV阳性女性进行回顾性分析，并根据宫颈细胞学筛查（ThinPrep细胞学检测，TCT）评估结合阴道镜，将其分组。其中，HPV16感染率最高。每组中，HPV16最为常见，并在四组之间存在显著差异（χ2=23.41，P=0.0001）。在每组中，HPV16和HPV33的分布与病理分期相关。mRNA测试的混合感染率在不同组间差异显著（P<0.01，χ2=17.44，P=0.002）。感染持续时间不满六个月的HR-HPV感染占87.65%，持续6至12个月的感染占28.28%，持续一年以上的感染仅占16.48%。在感染持续时间超过12个月的组中，前三种HPV类型分别为HPV52（3.03%）、HPV16（2.55%）和HPV39（1.58%）。持续12个月以上的感染中，清除最少的类型为HPV39（63.48%）、HPV56（69.54%）和HPV52（71.44%）。该研究揭示了不同宫颈病变中该地区的主要致病亚型，并为诊断和治疗HPV感染提供了基础。版权所有 © 2023 Elsevier Masson SAS 发布。

High-risk human papillomavirus (HR-HPV) infection is a major cause of infection-related cancer worldwide. 3,101 HR-HPV-positive females were retrospectively analyzed and grouped using the cervical cytological screening (ThinPrep cytological test, TCT) evaluations combined with colposcopy. The HPV16 infection rate is the highest in all groups. HPV16 was the most frequent in each group, with significant differences between the four groups (χ2=23.41, P=0.0001). The distribution of HPV16 and HPV33 correlated with the pathologic stage in each group. The mixed infection rate of mRNA testing differs significantly between groups (P<0.01, χ2=17.44, P=0.002). HR-HPV infection duration of less than six months accounted for 87.65%, 6 and 12 months of persistent infection (28.28%), and more than one year of continuous infection accounted for only 16.48%. The top three HPV types in a group with a duration of more than 12 months were HPV52 (3.03%), HPV16 (2.55%), and HPV39 (1.58%). The least clearance types were HPV39 (63.48%), 56 (69.54%), and 52 (71.44%) more than 12 months. This study revealed the region's primary pathogenic subtypes on different cervical lesions and provided the basis for diagnosing and treating HPV infection.Copyright © 2023. Published by Elsevier Masson SAS.