表浅性纤维母细胞瘤(胶原纤维瘤):对11例病例的临床病理学研究。
Superficial desmoplastic fibroblastoma (collagenous fibroma): Clinicopathologic study of 11 cases.
发表日期:2023 Sep 04
作者:
Ahmed Bakhshwin, Gabriel Oaxaca, Susan Armstrong, Jennifer Ko, Steven Billings
来源:
MEDICINE & SCIENCE IN SPORTS & EXERCISE
摘要:
结缔组织样纤维母细胞瘤(胶原纤维瘤)是一种少见的软组织肿瘤,通常发生在皮下或骨骼肌肉中。浅表于筋膜的病例并不常见,可能导致诊断困难。我们报告了11例浅表结缔组织样纤维母细胞瘤,涉及广泛的解剖分布。通过在2012年至2022年的10年期间,使用“结缔组织样纤维母细胞瘤”这一术语进行档案搜索。检索到浅表于筋膜的病例,并记录可用的临床病理特征。仅包括涉及真皮的病例。共鉴定了11例,所有病例均在协商会诊中接收。肿瘤涉及头颈部(2例)、下肢(2例)、背部(2例)、足部(1例)、肩部(1例)、腋窝(1例)、手部(1例)和乳房(1例)。每个病例都包括一个细胞贫瘠的伪星状至纺锤状成分,镶嵌在胶原纤维至局部黏液样基质中。可供查看的免疫组化染色显示SMA阳性(4/7),CD34阴性(0/6),EMA阴性(0/3),Desmin阴性(0/3)和S100阴性(0/7)。结缔组织样纤维母细胞瘤可能在真皮至皮下呈现浅表性质,对诊断存在潜在的困难。认识到结缔组织样纤维母细胞瘤的典型组织病理学特征,并合理使用免疫组化染色,应能实现准确的诊断。© 2023 The Authors. Journal of Cutaneous Pathology由John Wiley & Sons Ltd.出版。
Desmoplastic fibroblastoma (collagenous fibroma) is a rare soft tissue tumor that usually arises in the subcutis or skeletal muscle. Cases superficial to fascia are unusual and can cause diagnostic difficulty. We present 11 cases of superficial desmoplastic fibroblastoma involving a wide anatomic distribution.Archives were searched using the term "desmoplastic fibroblastoma" over a 10-year period (2012-2022). Cases superficial to fascia were retrieved, and available clinicopathologic features were recorded. Only cases involving the dermis were included.Eleven cases were identified, all of which were received in consultation. Tumors involved the head and neck (2), lower extremity (2), back (2), foot (1), shoulder (1), axilla (1), hand (1), and breast (1). Each consisted of a hypocellular proliferation of bland stellate to spindled fibroblasts set in a collagenous to focally myxoid stroma. The immunohistochemical stains available for review demonstrated SMA positivity (4/7) and negative immunoreactivity for CD34 (0/6), EMA (0/3), desmin (0/3), and S100 (0/7).Desmoplastic fibroblastoma may present superficially in the dermis to subcutis, posing a potential source of diagnostic difficulty. Recognition of the characteristic histopathologic features of desmoplastic fibroblastoma with judicial use of immunohistochemical stains should allow for accurate diagnosis.© 2023 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.