胆管癌（CCA）是起源于胆管上皮细胞的恶性肿瘤，其具有诊断困难和治疗选择有限的特点。自噬是一种细胞存活机制，它维持营养和能量稳态，清除细胞内病原体。它参与各种生理和病理过程，包括癌症的发展。然而，自噬在CCA中的作用、机制和潜在治疗靶点尚未得到深入研究。本综述介绍了自噬的分类、特征、过程和相关调节基因。我们总结了自噬对CCA进展的调节作用，并搜集了一些具有临床潜力的自噬调节剂在CCA中的最新研究进展。总之，将自噬调节剂与免疫治疗、化疗和靶向治疗相结合在CCA治疗中具有巨大潜力。该组合可能是未来CCA的潜在治疗靶点。© 2023. 细胞死亡分化学会 (ADMC)。

Cholangiocarcinoma (CCA) is a malignant tumor that originates from the biliary epithelial cells. It is characterized by a difficult diagnosis and limited treatment options. Autophagy is a cellular survival mechanism that maintains nutrient and energy homeostasis and eliminates intracellular pathogens. It is involved in various physiological and pathological processes, including the development of cancer. However, the role, mechanism, and potential therapeutic targets of autophagy in CCA have not been thoroughly studied. In this review, we introduce the classification, characteristics, process, and related regulatory genes of autophagy. We summarize the regulation of autophagy on the progression of CCA and collect the latest research progress on some autophagy modulators with clinical potential in CCA. In conclusion, combining autophagy modulators with immunotherapy, chemotherapy, and targeted therapy has great potential in the treatment of CCA. This combination may be a potential therapeutic target for CCA in the future.© 2023. Cell Death Differentiation Association (ADMC).