酸敏感离子通道1a在酸中毒相关疾病中对凋亡的调控：对治疗干预的启示。
Acid-sensing ion channel 1a modulation of apoptosis in acidosis-related diseases: implications for therapeutic intervention.
发表日期：2023 Sep 04
作者：
Zhenyu Zhang, Minnan Chen, Wenjing Zhan, Yuechun Chen, Tongtong Wang, Zhonghua Chen, Yifei Fu, Gang Zhao, Dong Mao, Jingjing Ruan, Feng-Lai Yuan
来源：
Arthritis & Rheumatology
摘要：
酸敏感离子通道1a (ASIC1a) 是酸敏感离子通道 (ASIC) 超家族的杰出成员，可以被细胞外质子激活，并广泛分布于人体各处，包括神经系统和周围组织。在血液或局部组织的酸性微环境中，通过ASIC1a激活可导致Ca2+离子的过度积累。ASIC1a介导的Ca2+诱导的细胞凋亡已与多种病理过程相关，包括神经系统疾病、癌症和类风湿性关节炎。本综述总结了ASIC1a在不同疾病状态下通过多种信号传导途径调节细胞凋亡的作用，为未来的研究提供了潜在机制和治疗策略的见解。© 2023. 细胞死亡与分化协会 (ADMC)。
Acid-sensing ion channel 1a (ASIC1a), a prominent member of the acid-sensing ion channel (ASIC) superfamily activated by extracellular protons, is ubiquitously expressed throughout the human body, including the nervous system and peripheral tissues. Excessive accumulation of Ca2+ ions via ASIC1a activation may occur in the acidified microenvironment of blood or local tissues. ASIC1a-mediated Ca2+‑induced apoptosis has been implicated in numerous pathologies, including neurological disorders, cancer, and rheumatoid arthritis. This review summarizes the role of ASIC1a in the modulation of apoptosis via various signaling pathways across different disease states to provide insights for future studies on the underlying mechanisms and development of therapeutic strategies.© 2023. Cell Death Differentiation Association (ADMC).