间充质干细胞（MSCs）因其能够发生肿瘤趋化迁移的能力而引起了人们的极大兴趣，因此被视为癌症治疗的有希望方法。MSCs具有有选择地迁向肿瘤的独特能力，使其成为将溶瘤病毒（OVs）有针对性地传递给治疗孤立性肿瘤和转移性恶性肿瘤的理想候选者。 OV因其能够有选择性地感染和破坏肿瘤细胞而不伤害正常细胞而受到人们关注，此外，OV能够诱导免疫性细胞死亡，并在其基因组中携带有治愈性转基因，使其成为与免疫疗法结合治疗癌症的理想候选者。与MSCs结合，OVs可以调节肿瘤微环境并触发抗肿瘤免疫反应，使得释放MSC的OV成为癌症治疗的有希望方法。本研究回顾了利用释放MSC的OV作为治疗癌症的一种新方法的研究。 视频摘要。©2023年。BioMed Central Ltd，Springer Nature的一部分。

Mesenchymal stem cells (MSCs) have attracted considerable interest as a promising approach for cancer treatment due to their ability to undergo tumor-trophic migration. MSCs possess the unique ability to selectively migrate to tumors, making them an excellent candidate for targeted delivery of oncolytic viruses (OVs) to treat isolated tumors and metastatic malignancies. OVs have attracted attention as a potential treatment for cancer due to their ability to selectively infect and destroy tumor cells while sparing normal cells. In addition, OVs can induce immunogenic cell death and contain curative transgenes in their genome, making them an attractive candidate for cancer treatment in combination with immunotherapies. In combination with MSCs, OVs can modulate the tumor microenvironment and trigger anti-tumor immune responses, making MSC-releasing OVs a promising approach for cancer treatment. This study reviews researches on the use of MSC-released OVs as a novel method for treating cancer. Video Abstract.© 2023. BioMed Central Ltd., part of Springer Nature.