膜状尿道长度与RARP后的尿失禁之关联:一项系统综述和荟萃分析。
Membranous Urethral Length and Urinary Incontinence post RARP? A Systematic Review and Meta-Analysis.
发表日期:2023 Sep 04
作者:
Benjamin M Mac Curtain, Diarmuid D Sugrue, Wanyang Qian, Michael O' Callaghan, Niall F Davis
来源:
BJU INTERNATIONAL
摘要:
为了提供有关术前膜状尿道长度(MUL)与术后尿失禁(UI)在接受机器人辅助根治性前列腺切除术(RARP)/机器人辅助腹腔镜前列腺切除术(RALP)的男性之间的关联的最新进展。UI在RARP / RALP术后很常见,而早期的恢复尿失禁是手术后最重要的功能结果之一。已经确定了MUL与RARP / RALP后膀胱控制恢复的相关因素。根据PRISMA指南,在Pubmed、Embase和Scopus数据库中进行了系统性回顾。纳入标准是最近五年内评估使用扩展前列腺癌指标复合物(EPIC)评估尿失禁的英文全文期刊文章。使用回顾性队列研究的关键评价技能计划(CASP)工具评估研究质量。进行随机效应荟萃分析,汇总可用研究中与MUL相关的尿失禁的比值比。使用Grading of Recommendations, Assessment, Development and Evaluations(GRADE)框架综合证据。包括970名患者的六项研究报告了MUL与12个月尿失禁之间的关联。较长的MUL与术后12个月尿失禁减少有关(汇总比值比= 0.74,CI 0.68-0.87,p<0.001)。遇到了显著的方法学和统计学异质性。MRI测量的术前MUL与接受RARP / RALP的男性术后膀胱控制显著相关。我们建议在RARP / RALP之前考虑MRI测量的MUL,以指导该人群的治疗决策。
To provide an update on the association between preoperative membranous urethral length (MUL) and postoperative urinary incontinence (UI) in men who undergo robot assisted radical prostatectomy (RARP) / robot assisted laparoscopic prostatectomy (RALP).UI is common after RARP / RALP, and early recovery of continence is one of the most important functional outcomes following surgery. MUL has been identified as a factor associated with continence recovery following RARP / RALP.A systematic review was carried out according to PRISMA guidelines, using Pubmed, Embase, and Scopus databases. Inclusion criteria were English language full journal articles from the last five years that assessed continence using the Expanded Prostate Cancer Index Composite (EPIC). The Critical Appraisal Skills Programme (CASP) tool for retrospective cohort studies was used to evaluate study quality. A random-effects meta-analysis was performed to pool odds ratios from available studies relating to continence as a function of MUL. The Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework was used to synthesise evidence.Six studies including 970 patients reported an association between MUL and continence at 12 months. Longer MUL was associated with reduced incontinence odds at 12-months post-surgery (Pooled OR = 0.74, CI 0.68 - 0.87, p < 0.001). Significant methodological and statistical heterogeneity was encountered.Preoperative MUL measured on MRI is significantly associated with postoperative continence in men undergoing RARP / RALP. We recommend consideration of MRI measurement of MUL prior to RARP / RALP to guide treatment decisions in this population.This article is protected by copyright. All rights reserved.