已经有研究显示，在宫颈鳞状细胞癌中，表观遗传作用基因的功能丧失以及PIK3CA通路的驱动基因变异与不良预后显著相关。最近，通过CoxBoost分析确定了16个基因变异和30个高度活化的蛋白质，因为它们与放化疗所导致的治疗结果显著相关，对这些结果感到极度关注。本研究的目标是回顾和确认这些分子变化的重要性，正如文献报道所建议的，并为对放化疗反应不良的患者提供替代治疗方案。© 2023. 亚洲妇产科学会，韩国妇产科学会和日本妇产科学会。

Loss of function in epigenetic acting genes together with driver alterations in the PIK3CA pathway have been shown significantly associated with poor outcome in cervical squamous cell cancer. More recently, a CoxBoost analysis identified 16 gene alterations and 30 high level activated proteins to be of high interest, due to their association with either good or bad outcome, in the context of treatment received by chemoradiation. The objectives here were to review and confirm the significance of these molecular alterations as suggested by literature reports and to pinpoint alternate treatments options for poor-responders to chemoradiation.© 2023. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology.