基准标准有助于改善手术结果。然而，目前尚无关于经鞍腔手术的最佳可实现结果的国际认可标准。我们的目标是建立垂体腺瘤经鞍腔手术的标准化结果基准标准。共分析了来自三大洲九个专家中心的2685例经鞍腔瘤肿瘤切除手术。患者进行了风险分层，并确定了各个中心结果的中值。基准标准被定义为特定结果的所有中值的第75百分位数。术后基准结果包括手术因素、内分泌特定指标和神经学特定指标。在2685例患者中，1149例（42.8%）确定为低风险基准组。在这些基准病例中，831例（72.3%）患者接受了显微镜下经鼻内窥镜手术（MTS），308例（26.8%）患者接受了内窥镜内切除术（EES）。所有肿瘤中，799例（29.8%）侵犯了海绵窦。术后并发症发生率为19.6%，死亡率为0.0-0.8%。基准截断值为再手术率≤2.9%，需要干预的脑脊液漏率≤1.9%，短暂性尿崩症率≤15.5%。6个月后，基准截断值计算如下：再住院率≤6.9%，新发低垂体功能≤6.0%，肿瘤残留≤19.2%。本分析定义了针对经鞍腔手术的基准值，以评估术后的发病率和死亡率，并代表了专家中心中最佳患者的最佳结果。这些截断值可用于评估不同中心、患者群体和新的手术技术。应注意，基准值可能会相互影响，必须在其自身的背景下进行评估。©作者（2023）。由牛津大学出版社代表欧洲内分泌学协会出版。保留所有权利。有关许可，请发送电子邮件至：journals.permissions@oup.com。

Benchmarks aid in improve outcomes for surgical procedures. However, best achievable results that have been validated internationally for transsphenoidal surgery (TS) are not available. We aimed to establish standardized outcome benchmarks for transsphenoidal surgery of pituitary adenomas.A total of 2685 transsphenoidal tumor resections from 9 expert centers in 3 continents were analyzed. Patients were risk stratified and the median values of each center's outcomes were established. The benchmark was defined as the 75th percentile of all median values for a particular outcome. The postoperative benchmark outcomes included surgical factors, endocrinology-specific values, and neurology-specific values.Of 2685 patients, 1149 (42.8%) defined the low-risk benchmark cohort. Within these benchmark cases, 831 (72.3%) patients underwent microscopic (MTS) and 308 (26.8%) patients endoscopic endonasal resection (EES). Of all tumors, 799 (29.8%) cases invaded the cavernous sinus. The postoperative complication rate was 19.6% with a mortality between 0.0-0.8%. Benchmark cutoffs were ≤ 2.9% for reoperation rate, ≤ 1.9% for CSF leak requiring intervention, and ≤ 15.5% for transient diabetes insipidus. At 6 months, benchmark cutoffs were calculated as follows: readmission rate: ≤ 6.9%, new hypopituitarism ≤ 6.0%, and tumor remnant ≤ 19.2%.This analysis defines benchmark values for TS targeting morbidity and mortality and represent the best outcomes in the best patients in expert centers. These cutoffs can be used to assess different centers, patients' populations, and novel surgical techniques. It should be noted that the benchmark values may influence each other and must be evaluated in their own context.© The Author(s) 2023. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.