为了评估接受辅助治疗与否的老年女性子宫内膜癌（EC）患者的体能功能（PF）的变化，我们研究了女性健康倡议癌后生活与长寿队列中年龄≥70岁的EC患者，并分析了可用的治疗记录。我们使用RAND-36量表测量了PF的变化，并采用Wilcoxon秩和检验比较了各组之间的差异。为了对混杂变量进行调整，我们使用多变量中位数回归法比较了评分的变化。研究纳入了287名女性，其中150名（52.3％）未接受辅助治疗，137名（47.7％）接受了辅助治疗。在比较体能功能评分时，接受辅助治疗的患者的功能下降中位数百分比变化有显著差异，其下降更大（-5.9％ [-23.5至0％]），而未接受辅助治疗的患者的变化范围为0（[-18.8至+6.7％]），p = 0.02）。在多变量调整后，结果在统计学上没有显著差异，但接受化疗的患者的百分数变化更大（中位数Δ-13.8％ [-35.5至0%]）,相比之下仅接受放射治疗的患者（中位数Δ-5.9％ [-31.3至0%]）或同时接受化疗和放射治疗的患者（中位数Δ-6.5％ [-25.8至+5.7%]）。接受辅助治疗的EC患者的PF变化超过了未接受辅助治疗的患者，特别是接受化疗的女性。这些结果在多变量分析中没有统计学上的显著差异。EC幸存者可能会因为化疗和/或放疗而经历PF的变化。需要为老年妇女提供额外的支持性护理，以减轻功能下降。© 2023. 作者（专利所有人）独家授权给Springer Science+Business Media, LLC，属于Springer Nature的一部分。

To evaluate changes in physical function (PF) for older women with endometrial cancer (EC) + / - adjuvant therapy in the Women's Health Initiative Life and Longevity after Cancer cohort.This study examined women ≥ 70 years of age with EC with available treatment records. Change in PF was measured using the RAND-36 and compared between groups using Wilcoxon rank-sum tests. Multivariable median regression was used to compare the changes in scores while adjusting for confounding variables.Included in the study were 287 women, 150 (52.3%) women who did not receive adjuvant therapy and 137 (47.7%) who received adjuvant therapy. When comparing PF scores, there was a statistically significant difference in the median percent change in functional decline, with a greater decline in those who received adjuvant therapy (- 5.9% [- 23.5 to 0%]) compared to those who did not (0 [- 18.8 to + 6.7%]), p = 0.02). Results were not statistically significant after multivariable adjustment, but women who underwent chemotherapy had a greater percent change (median ∆ - 13.8% [- 35.5 to 0%]) compared to those who received radiation alone (median ∆ - 5.9% [- 31.3 to 0%]) or chemotherapy and radiation (median ∆ - 6.5% [- 25.8 to + 5.7%].Older women with EC who received adjuvant therapy experienced greater change in PF than those who did not receive adjuvant therapy, particularly women who received chemotherapy. These results were not statistically significant on multivariate analysis.EC survivors may experience changes in PF because of chemotherapy and/or radiation therapy. Additional supportive care may need to be provided to older women to mitigate functional decline.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.