小泛素样修饰(SUMOylation)是一种重要的转录后修饰，具有广泛的生物学功能，包括基因组复制与修复、转录调控、蛋白稳定性和细胞周期进展等。SUMOylation和去SUMOylation状态的紊乱已成为肺部疾病的新的病理生理特征。在本综述中，我们重点强调了SUMO途径与肺部疾病的联系，特别是在支气管肺发育不良（BDP）中的C/EBPα的SUMO化底物、在肺炎中的PPARγ、在哮喘中的TFII-I、在慢性阻塞性肺疾病（COPD）中的HDAC2、在缺氧性肺动脉高压（HPH）中的KLF15、在特发性肺纤维化（IPF）中的SMAD3，以及在癌症中的YTHDF2。通过探索SUMOylation在肺部疾病中的影响，我们旨在揭示其对诊断和治疗策略创新的潜力，有望改善患者预后和整体呼吸健康。 © 2023. 费因斯坦医学研究所。

Small ubiquitin-like modifier mediated modification (SUMOylation) is a critical post-translational modification that has a broad spectrum of biological functions, including genome replication and repair, transcriptional regulation, protein stability, and cell cycle progression. Perturbation or deregulation of a SUMOylation and deSUMOylation status has emerged as a new pathophysiological feature of lung diseases. In this review, we highlighted the link between SUMO pathway and lung diseases, especially the sumoylated substrate such as C/EBPα in bronchopulmonary dysplasia (BDP), PPARγ in pneumonia, TFII-I in asthma, HDAC2 in chronic obstructive pulmonary disease (COPD), KLF15 in hypoxic pulmonary hypertension (HPH), SMAD3 in idiopathic pulmonary fibrosis (IPF), and YTHDF2 in cancer. By exploring the impact of SUMOylation in pulmonary diseases, we intend to shed light on its potential to inspire the development of innovative diagnostic and therapeutic strategies, holding promise for improving patient outcomes and overall respiratory health.© 2023. The Feinstein Institute for Medical Research.