在阿尔茨海默病的发病机制中，多项研究提出了T细胞的重要作用。鉴于免疫治疗在癌症和各种疾病中的成功应用，T细胞调节治疗成为发展阿尔茨海默病和可能的神经退行性疾病新疗法的一种有吸引力的途径。然而，大部分研究都是关于外周T细胞反应，而直接证明了T细胞浸润与阿尔茨海默病病理标记物（即淀粉样斑块和神经原纤维缠结）相关的病理证据稀缺，最多只是在人体和相关动物模型中初步存在。在这里，我们简要总结了直接与T细胞浸润相关的可用病理数据，对当前知识空白进行了批判性分析，并深思熟虑地提出了几项未来研究的关键建议。版权所有© Bentham Science Publishers；如有任何疑问，请发送电子邮件至 epub@benthamscience.net。

Multiple studies have proposed important roles of T cells in the pathogenesis of Alzheimer's disease. Given the successful application of immune-based therapy for cancer and a variety of diseases, T cell-modifying therapy becomes an attractive way to develop new therapies for Alzheimer's disease and perhaps neurodegenerative diseases in general. However, most of these studies address peripheral T cell responses, while direct pathological evidence documenting T cell infiltration relative to Alzheimer's disease pathological markers (i.e., amyloid plaque and neurofibrillary tangle) is sparse and at best, very preliminary in both human subjects and relevant animal models. Here, we concisely summarize the available pathological data that directly corresponds to T cell infiltration, critically analyze the current knowledge gaps, and thoughtfully propose several key recommendations for future research.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.