每年约有80万人死于乙型肝炎病毒（HBV）感染。在感染的成年人中，大约有5%的人免疫系统无法有效对抗HBV感染，导致慢性乙型肝炎（CHB）。CHB与肝细胞癌相关，可能导致患者死亡。不幸的是，尽管目前针对CHB的治疗可以控制HBV感染，但无法完全根除病毒。IFN家族细胞因子是先天免疫系统的一部分，是病毒消除的关键角色。IFN的分泌诱导干扰素诱导基因的表达，产生具有抗病毒特性的蛋白质，对细胞自主免疫至关重要。IFN-α通常用作治疗CHB的方法。此外，IFN-γ已被确定为在急性感染期间清除HBV的主要IFN家族成员。在本综述中，我们总结了通过细胞或动物模型从HBV复制或感染方面获得的关于IFN-γ潜在抗HBV作用的关键证据，特别关注IFN-γ诱导基因。版权所有 © 2023. 韩国免疫学家协会。

About 0.8 million people die because of hepatitis B virus (HBV) infection each year. In around 5% of infected adults, the immune system is ineffective in countering HBV infection, leading to chronic hepatitis B (CHB). CHB is associated with hepatocellular carcinoma, which can lead to patient death. Unfortunately, although current treatments against CHB allow control of HBV infection, they are unable to achieve complete eradication of the virus. Cytokines of the IFN family represent part of the innate immune system and are key players in virus elimination. IFN secretion induces the expression of interferon stimulated genes, producing proteins that have antiviral properties and that are essential to cell-autonomous immunity. IFN-α is commonly used as a therapeutic approach for CHB. In addition, IFN-γ has been identified as the main IFN family member responsible for HBV eradication during acute infection. In this review, we summarize the key evidence gained from cellular or animal models of HBV replication or infection concerning the potential anti-HBV roles of IFN-γ with a particular focus on some IFN-γ-inducible genes.Copyright © 2023. The Korean Association of Immunologists.