胞外囊泡的功能和临床应用：如何提升肿瘤免疫疗法？ 摘要：肿瘤免疫疗法作为一种新型的治疗方法，已被广泛应用于肿瘤治疗。然而，存在一些挑战，如免疫耐受性和耐药性。近年来，越来越多的研究表明胞外囊泡（exosome）在调节免疫反应中发挥着重要的作用。因此，研究人员开始探索如何利用这种生物活性小颗粒来改善肿瘤免疫疗法的效果。本文综述了胞外囊泡的功能和临床应用，并讨论了提高肿瘤免疫疗法的方法。 关键词：胞外囊泡，肿瘤免疫疗法，免疫耐受性，耐药性，生物活性小颗粒
Function and clinical application of exosome-how to improve tumor immunotherapy?
发表日期：2023
作者：
Siwen Qin, Jilong Cao, Xiaoxue Ma
来源：
Frontiers in Cell and Developmental Biology
摘要：
近年来，免疫治疗在临床实践中越来越多地用于肿瘤治疗。然而，免疫治疗的疗效在不同肿瘤类型和患者群体之间存在差异，且治疗过程中常常发生长期耐药。因此，探索免疫治疗的分子机制以提高其疗效是至关重要的。在本综述中，我们关注肿瘤源性外泌体在临床治疗中的重要性，以及如何修饰这些外泌体可以增强免疫效应。具体而言，我们讨论外泌体成分，如RNA、脂质和蛋白质，以及外泌体表面的膜分子的作用。此外，我们强调了工程改造外泌体在肿瘤免疫治疗中的重要性。我们的目标是提出改善肿瘤免疫治疗疗效的新策略。版权所有 © 2023 Qin、Cao 和 Ma。
In recent years, immunotherapy has been increasingly used in clinical practice to treat tumors. However, immunotherapy's efficacy varies between tumor types and patient populations, and long-term drug resistance often occurs during treatment. Therefore, it is essential to explore the molecular mechanisms of immunotherapy to improve its efficacy. In this review, we focus on the significance of tumor-derived exosomes in the clinical treatment of tumors and how modifying these exosomes may enhance immune effectiveness. Specifically, we discuss exosome components, such as RNA, lipids, and proteins, and the role of membrane molecules on exosome surfaces. Additionally, we highlight the importance of engineered exosomes for tumor immunotherapy. Our goal is to propose new strategies to improve the efficacy of tumor immunotherapy.Copyright © 2023 Qin, Cao and Ma.