骨肉瘤（OS）是青少年中最常见的恶性骨肿瘤，OS的临床治疗主要包括手术、放疗和化疗。然而，化疗药物的副作用是临床医生不能忽视的问题。纳米医学和药物传递技术在现代医学中扮演着重要角色。纳米医学的发展带来了肿瘤治疗新的转折点。随着纳米颗粒的出现和发展，纳米颗粒能够设计具有不同靶向效应的能量表面。不仅如此，纳米颗粒在药物传递方面也具有独特优势。纳米颗粒输送药物不仅可以减少化疗药物的毒性副作用，而且由于肿瘤细胞的增强渗透保留（EPR）特性，纳米颗粒可以在肿瘤微环境中存活更长时间，并持续释放载体给肿瘤细胞。临床前研究已经证实，纳米颗粒可以有效延缓肿瘤生长，提高OS患者的生存率。在本文中，我们介绍了纳米颗粒在OS治疗中的不同功能，并展望了改进纳米颗粒在OS治疗中的未来前景。Copyright © 2023 Zhang, Luo and Huang.

Osteosarcoma (OS) is the most common malignant bone tumor in adolescents, and the clinical treatment of OS mainly includes surgery, radiotherapy, and chemotherapy. However, the side effects of chemotherapy drugs are an issue that clinicians cannot ignore. Nanomedicine and drug delivery technologies play an important role in modern medicine. The development of nanomedicine has ushered in a new turning point in tumor treatment. With the emergence and development of nanoparticles, nanoparticle energy surfaces can be designed with different targeting effects. Not only that, nanoparticles have unique advantages in drug delivery. Nanoparticle delivery drugs can not only reduce the toxic side effects of chemotherapy drugs, but due to the enhanced permeability retention (EPR) properties of tumor cells, nanoparticles can survive longer in the tumor microenvironment and continuously release carriers to tumor cells. Preclinical studies have confirmed that nanoparticles can effectively delay tumor growth and improve the survival rate of OS patients. In this manuscript, we present the role of nanoparticles with different functions in the treatment of OS and look forward to the future treatment of improved nanoparticles in OS.Copyright © 2023 Zhang, Luo and Huang.