胃癌中lncRNA的景观：从分子机制到潜在临床应用
The landscape of lncRNAs in gastric cancer: from molecular mechanisms to potential clinical applications.
发表日期：2023
作者：
Jéssica Manoelli Costa Silva, Eliel Barbosa Teixeira, Ronald Matheus da Silva Mourão, Rafaella Sousa Ferraz, Fabiano Cordeiro Moreira, Paulo Pimentel de Assumpção, Danielle Queiroz Calcagno
来源：
Frontiers in Pharmacology
摘要：
胃癌（GC）是全球高发且致命的恶性肿瘤。当前，长链非编码RNA（lncRNA）最近被确认为在GC的发展和进展中扮演着重要调控因子。lncRNA的异常表达通常与肿瘤迁移、侵袭性增强以及治疗抵抗相关，突显了它们作为临床应用前景的潜力目标。本综述为GC中lncRNA的全面历史概述，描述了其分子机制，并讨论了建立lncRNA作为精准生物标志物的前景和挑战。
版权所有©2023 Silva, Teixeira, Mourão, Ferraz, Moreira, Assumpção和Calcagno。
Gastric cancer (GC) is a highly prevalent and deadly malignant neoplasm worldwide. Currently, long non-coding RNAs (lncRNAs) have recently been identified as crucial regulators implicated in GC development and progression. Dysregulated expression of lncRNAs is commonly associated with enhanced tumor migration, invasiveness, and therapy resistance, highlighting their potential as promising targets for clinical applications. This review offers a comprehensive historical overview of lncRNAs in GC, describes the molecular mechanisms, and discusses the prospects and challenges of establishing lncRNAs as precision biomarkers.Copyright © 2023 Silva, Teixeira, Mourão, Ferraz, Moreira, Assumpção and Calcagno.