癌症是与年龄相关的疾病，大多数患者在60岁后被诊断，并且大多数癌症死亡发生在这个年龄之后。肿瘤微环境随年龄而变化，进而影响癌症的进展和治疗效果。过去几十年来，微环境中个别成分的年龄相关变化受到了应有的注意，但两个或更多微环境成分之间衰老的效应却鲜为人知。在这个视角中，我们讨论了衰老的细胞外基质和衰老的免疫系统之间的关系，以及它们如何影响肿瘤微环境，以及这些多学科研究如何为新的治疗方法开辟通路。癌症是一种与年龄有关的疾病。随着人口老龄化的迅速发展，我们需要更好地了解推动肿瘤发展的与年龄相关的变化，从分泌性变化到生物物理和免疫变化。©2023美国癌症研究协会。

Cancer is an age-related disease, with the majority of patients receiving their diagnosis after the age of 60 and most mortality from cancer occurring after this age. The tumor microenvironment changes drastically with age, which in turn affects cancer progression and treatment efficacy. Age-related changes to individual components of the microenvironment have received well-deserved attention over the past few decades, but the effects of aging at the interface of two or more microenvironmental components have been vastly understudied. In this perspective, we discuss the relationship between the aging extracellular matrix and the aging immune system, how they affect the tumor microenvironment, and how these multidisciplinary studies may open avenues for new therapeutics. Cancer is a disease of aging. With a rapidly aging population, we need to better understand the age-related changes that drive tumor progression, ranging from secreted changes to biophysical and immune changes.©2023 American Association for Cancer Research.