信号调节蛋白α（SIRPα）是表达在骨髓源细胞表面的一个重要的抑制性调节因子，包括巨噬细胞、树突状细胞（DCs）、单核细胞、中性粒细胞和微胶质细胞。在癌症免疫学、组织稳态和其他生理或生物心理情况下，SIRPα在先天免疫和适应性免疫反应中发挥着不可或缺的作用。本文回顾了与SIRPα相关的研究历史、配体、信号转导途径和功能机制，并总结了以SIRPα为靶点的治疗在免疫肿瘤学中作为一种有前景的新策略的治疗意义。本文受版权保护。版权所有。

Signal regulatory protein alpha (SIRPα) is a crucial inhibitory regulator expressed on the surface of myeloid cells, including macrophages, dendritic cells (DCs), monocytes, neutrophils and microglia. SIRPα plays an indispensable role in innate immune and adoptive immune responses in cancer immunology, tissue homeostasis and other physiological or phycological conditions. This review provides an overview of the research history, ligands, signal transduction pathways and functional mechanisms associated with SIRPα. Additionally, we summarize the therapeutic implications of targeting SIRPα as a promising novel strategy in immuno-oncology. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.