点对点（PoC）测试正革新医疗保健部门，在日常医院实践中改善患者护理，并能覆盖偏远地区。在癌症管理范畴内，迫切需要设计和验证能够非侵入性快速检测癌症标志物的PoC设备，以便在临床实践中实施液体活检。因此，着重于具有高特异性的稳定血液标志物（如微型RNA）具有重要意义。本研究重点讨论循环微型RNA检测对癌症管理和PoC测试设备发展的潜在影响，特别是对于低收入国家而言。同时，我们还详细讨论了在推动技术转移和临床应用这些工具时需要面对的挑战，以便为读者提供全面的潜力与当前限制的概述。© 2023 Wiley-VCH GmbH.

Point-of-care (PoC) testing is revolutionizing the healthcare sector improving patient care in daily hospital practice and allowing reaching even remote geographical areas. In the frame of cancer management, the design and validation of PoC enabling the non-invasive, rapid detection of cancer markers is urgently required to implement liquid biopsy in clinical practice. Therefore, focusing on stable blood-based markers with high-specificity, such as microRNAs, is of crucial importance. In this work, we highlight the potential impact of circulating microRNAs detection on cancer management and the development of PoC testing devices, especially for low-income countries. A detailed discussion about the challenges that should be faced to promote the technological transfer and clinical use of these tools has been added, to provide the readers with a complete overview of potentialities and current limitations.© 2023 Wiley-VCH GmbH.