为了估计东部和南部墨西哥地区乙酰胆碱酯酶-亚氨基丙酸天冬酰胺 (AFB1-lys) 的检测频率和水平，该物质是肝细胞癌 (HCC) 的重要风险因素。我们在2018年对来自坎佩切、恰帕斯、塔毛利帕斯、韦拉克鲁斯和尤卡坦五个州的952名成年人 (加权n = 7,493,354) 进行了质谱分析检测其血清中的 AFB1-lys。我们计算了总体以及亚组特定的检测频率和95%置信区间 (95%CI)，以及中位数 AFB1-lys 水平和四分位数。AFB1-lys 的总体检测频率为91.9% (95%CI 88.6, 94.3)。中位数 AFB1-lys 水平为0.172 pg/μL (Q1-Q3, 0.060-0.582)。不同地理区域的水平存在差异 (中位数 pg/μL, 韦拉克鲁斯为0.361，尤卡坦为0.061)，而且男性和年长者的水平较高。乡村地区的水平几乎是城市地区的三倍 (0.317 vs. 0.123 pg/μL)。我们观察到低社会经济地位 (SES) 人群中 AFB1-lys 暴露水平较高。AFB1-lys 的检测频率非常高，并且在韦拉克鲁斯、男性、农村地区和低SES人群中暴露水平最高。了解具有独特流行病学模式人群中可改变的HCC风险因素，能为预防干预措施提供信息。 版权所有 © 2023 Elsevier GmbH. 保留所有权利。

To estimate the frequency of detection and levels of aflatoxin B1-lysine adduct (AFB1-lys), an important hepatocellular carcinoma (HCC) risk factor, in eastern and southern Mexico.We determined serum AFB1-lys using mass spectrometry in a representative sample of 952 adults (weighted n = 7,493,354) from five states (Campeche, Chiapas, Tamaulipas, Veracruz and Yucatán) in 2018. We calculated overall and subgroup-specific frequency of detection and 95% confidence intervals (95%CI) and median AFB1-lys levels and quartiles.The overall frequency of detection of AFB1-lys was 91.9% (95%CI 88.6, 94.3). The median AFB1-lys level was 0.172 pg/μL (Q1-Q3, 0.060-0.582). Levels differed geographically (median pg/μL, 0.361 for Veracruz and 0.061 for Yucatan) and were higher among men and older individuals. Levels were almost three times higher in rural relative to urban areas (0.317 vs. 0.123 pg/μL). We observed higher AFB1-lys exposure in lower socioeconomic status (SES) level populations.AFB1-lys frequency of detection was very high and exposure levels were highest in Veracruz, men, rural areas, and among persons of lower SES. Understanding modifiable HCC risk factors in populations with unique epidemiological patterns could inform preventative interventions.Copyright © 2023 Elsevier GmbH. All rights reserved.