基于修饰石墨烯的氮化铋纳米颗粒 (BiNPs/Gr/GCE) 构建了一种选择性和灵敏的伏安测量化疗药物顺磷胺铂的传感器。扫描电子显微镜 (SEM) 表征了电极的表面形貌。循环伏安法 (CV) 和电化学阻抗谱 (EIS) 评估了电化学特性。差分脉冲伏安法 (DPV) 用于检测顺磷胺铂的氧化过程。在最佳条件下，氧化峰电流与顺磷胺铂浓度在 6.0 至 180 μM 范围内呈线性增加。检测限计算为 4.4 μM，定量限为 14.7 μM。分析性能研究证明了 BiNPs/Gr/GCE 对顺磷胺铂检测的电极重现性和选择性。该开发的顺磷胺铂传感器成功应用于人体血清样品中的顺磷胺铂测量。回收率范围为 89% 至 102%，且与高效液相色谱-紫外检测分析结果一致 (P > 0.05)。版权所有 © 2023 Elsevier B.V. All rights reserved.

A selective and sensitive voltammetric sensor for the measurement of the chemotherapy drug cisplatin was based on bismuth nanoparticles decorated on a graphene-modified glassy carbon electrode (BiNPs/Gr/GCE). The surface morphologies of electrode modifications were characterized using scanning electron microscopy (SEM). Electrochemical characteristics were evaluated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Differential pulse voltammetry (DPV) was employed to detect cisplatin oxidation. Under the optimal conditions, oxidation peak currents increased linearly with cisplatin concentration from 6.0 to 180 μM. The detection limit was calculated to be 4.4 μM and the limit of quantification was 14.7 μM. Analytical performance studies demonstrated the good electrode reproducibility and the selectivity of the BiNPs/Gr/GCE towards cisplatin detection. The developed cisplatin sensor was successfully utilized to measure cisplatin in samples of human serum. Recoveries ranged from 89 to 102% and the results from the developed sensor were concordant (P > 0.05) with the results of analysis by high-performance liquid chromatography coupled with ultraviolet detection.Copyright © 2023 Elsevier B.V. All rights reserved.