电纺聚（ε-己内酯）（PCL）支架中药物的爆发性释放是有害的，对于细胞毒剂来说，由于在初始植入期间达到的毒性水平。在本短讯中，我们报告了由PCL和水溶性聚乙烯吡咯烷酮（PVP）制成的复合支架意外地能够长期释放广泛使用的抗癌药物多柔比星盐酸盐（DOX-HCl）。该效果观察到了基于PCL和PVP的电纺DOX-HCl负载复合支架（100/0，95/5，90/10，75/25和50/50）上。经过形态学和水接触角研究，得出结论，PVP含量对平均纤维直径无影响，而PVP含量高于10 wt.%会改变支架表面的亲水性特征（水接触角为123.9±3.5°）到超亲水性（水接触角为0°）。尽管水润湿性发生了显著改变，但通过高效液相色谱（HPLC）揭示，支架中的PVP含量能够减少DOX-HCl在磷酸盐缓冲盐水（PBS）的短期（首几小时）和长期（1个月期间）暴露下的释放速率。这些结果与体外研究相一致，在这些研究中，与高PVP含量的支架相比，HeLa宫颈癌细胞的活力在培养24小时后更高。版权所有 ©2023 Elsevier公司出版。

Burst release, typical for the drug-loaded electrospun poly(ε-caprolactone) (PCL) scaffolds is unfavorable in case of cytostatics due to the toxic levels reached during the initial implantation period. In the present short communication, we report an unexpected ability of the composite scaffolds made of PCL and water-soluble polyvinylpyrrolidone (PVP) to provide long-term release of widely used anti-cancer drug doxorubicin hydrochloride (DOX-HCl). That effect was observed for electrospun DOX-HCl-loaded composite scaffolds based on PCL and PVP with various mass ratios (100/0, 95/5, 90/10, 75/25 and 50/50). After the morphology and water contact angle studies, it was concluded that PVP content has no effect on the average fiber diameter, while PVP content higher 10 wt. % changes the hydrophobic character of the scaffolds surface (water contact angle of 123.9±3.5°) to superhydrophilic (water contact angle of 0°). Despite the dramatic change in water wettability, by high performance liquid chromatography (HPLC), it was revealed that the PVP content in the scaffolds reduces the DOX-HCl release rate under short (first hours) and long-term (during 1 month) exposure to phosphate buffer saline (PBS). These results are in good agreement with in vitro studies, in which the viability of HeLa cervical cancer cells was higher after 24 h of culture with scaffolds with high PVP content.Copyright © 2023. Published by Elsevier Inc.