姜黄素具有抗炎、抗氧化和抗癌作用，并用于治疗皮肤病、感染、应激、抑郁和焦虑等疾病。J147是姜黄素的类似物，经过改良合成以提高稳定性和生物利用度。累积的证据表明J147在预防和治疗阿尔茨海默病、糖尿病神经病变、缺血性中风、抑郁症、焦虑和脂肪肝病方面具有潜在作用。在本综述中，我们总结了J147的背景和生化特性，并讨论了J147在不同疾病中的作用和机制。总体而言，J147的机械属性使其成为预防和治疗神经性疾病的潜在靶点。© 2023. BioMed Central Ltd., part of Springer Nature.

Curcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is designed and synthesized with better stability and bioavailability. Accumulating evidence demonstrates the potential role of J147 in the prevention and treatment of Alzheimer's disease, diabetic neuropathy, ischemic stroke, depression, anxiety, and fatty liver disease. In this narrative review, we summarized the background and biochemical properties of J147 and discussed the role and mechanism of J147 in different diseases. Overall, the mechanical attributes of J147 connote it as a potential target for the prevention and treatment of neurological diseases.© 2023. BioMed Central Ltd., part of Springer Nature.