软组织肉瘤(STSs) 是一组杂多恶性肿瘤，其诊断、治疗和管理一直以来都带来了挑战。本综述回顾了 STS 这个复杂领域的多个方面，从历史起源到最新的研究和临床护理进展。我们深入探讨了 STS 的分子细节，突出了驱动这些肿瘤的遗传和表观遗传异常。本综述强调了 STS 在神经学方面的影响，这是一个相对不为人们所了解的领域，揭示了肿瘤生物学与神经过程之间的相互作用。我们讨论了不断发展的治疗方法，重点关注了靶向治疗、免疫治疗和精准医学的潜力。本综述的一个重要部分专门讨论了以患者为中心的方法，强调了关注 STS 患者身心需求的整体护理的重要性。此外，我们还突出了当前研究和临床实践中存在的差距，并提供了关于未来研究的潜在路径的见解。本综述为临床医生、研究人员和更广泛的科学界提供了宝贵的资料，总结了 STS 知识的当前状态，并指向了这一个动态领域的未来方向。版权所有 © 2023, Ekhator 等。

Soft tissue sarcomas (STSs) are a heterogeneous group of malignancies that have long posed challenges in terms of diagnosis, treatment, and management. This narrative review provides a comprehensive exploration into the multifaceted realm of STS, spanning from its historical origins to the latest advancements in research and clinical care. We delve into the molecular intricacies of STS, highlighting the genetic and epigenetic aberrations that drive these tumors. The review emphasizes the neurological implications of STS, a relatively underexplored area, shedding light on the interplay between tumor biology and neural processes. The evolving therapeutic landscape is discussed, with a focus on the promise of targeted therapies, immunotherapy, and precision medicine. A significant portion is dedicated to the patient-centric approach, underscoring the importance of holistic care that addresses both the physical and psychological needs of STS patients. Furthermore, we highlight the gaps in current research and clinical practices, offering insights into potential avenues for future exploration. This review serves as a valuable resource for clinicians, researchers, and the broader scientific community, encapsulating the current state of STS knowledge and pointing toward future directions in this dynamic field.Copyright © 2023, Ekhator et al.