尽管嵌合抗原受体（CAR）T细胞疗法在B细胞淋巴瘤和白血病的亚群中取得了非凡的成功，但各种障碍限制了其在实体肿瘤中的应用。这促使人们去研究新的方法来生产具有更高治疗潜力的CAR-T细胞。对CAR-T细胞临床成功的障碍的新认识表明，自噬通过重新编程细胞代谢来塑造免疫应答，反之亦然。自噬是一种自我吞食的过程，包括将细胞内组分破坏和回收于溶酶体中，影响T细胞的生物学，包括发育、存活、记忆形成和细胞代谢。在本综述中，我们将强调自噬在调控和改变CAR-T细胞代谢途径中的关键作用，以及CAR-T细胞的代谢状况和肿瘤微环境（TME）如何改变CAR-T细胞中的自噬调控，以恢复在穿越实体肿瘤微环境中的CAR-T细胞的功能能力。© 2023 Panahi Meymandi、Akbari、Soltantoyeh、Hadjati、Klionsky、Badie和Mirzaei版权所有。

Despite chimeric antigen receptor (CAR) T cell therapy's extraordinary success in subsets of B-cell lymphoma and leukemia, various barriers restrict its application in solid tumors. This has prompted investigating new approaches for producing CAR T cells with superior therapeutic potential. Emerging insights into the barriers to CAR T cell clinical success indicate that autophagy shapes the immune response via reprogramming cellular metabolism and vice versa. Autophagy, a self-cannibalization process that includes destroying and recycling intracellular components in the lysosome, influences T cell biology, including development, survival, memory formation, and cellular metabolism. In this review, we will emphasize the critical role of autophagy in regulating and rewiring metabolic circuits in CAR T cells, as well as how the metabolic status of CAR T cells and the tumor microenvironment (TME) alter autophagy regulation in CAR T cells to restore functional competence in CAR Ts traversing solid TMEs.Copyright © 2023 Panahi Meymandi, Akbari, Soltantoyeh, Hadjati, Klionsky, Badie and Mirzaei.