本研究旨在评估本地群众对人乳头瘤病毒（HPV）疫苗接种的认识、态度和知识的变化。其次目标是识别障碍，并评估新加坡六年间国家HPV疫苗接种活动的有效性。我们在2013年和2019年在一家妇科门诊对女性参与者进行了两次横断面调查，并进行了比较。2013年和2019年共有597名参与者完成了调查。参与者在种族、婚姻状况、教育水平、职业和月收入方面具有可比性。从2013年到2019年，有关子宫颈癌和HPV感染的知识分数显著提高。在HPV疫苗的知识分数方面没有显著差异，这导致了类似的HPV疫苗接种率。年龄、教育水平和对HPV疫苗的认知是接受HPV疫苗的重要预测因素。在2019年的调查中，拒绝接受HPV疫苗的两个主要原因是缺乏知识和费用。新加坡政府通过全国活动和政策变更努力提高子宫颈癌认识度，已经改善了HPV感染的知识。然而，这并没有转化为接受疫苗的增加。接受疫苗的决策是复杂的，并且有多个因素需要考虑以确保成本效益的实施策略。我们的研究强调了有关疫苗信息的有效传播的需要，额外的补贴和考虑强制性的学校接种计划。

This study aimed to assess the changes in the awareness, attitudes and knowledge regarding human papillomavirus (HPV) vaccination among the local population. The secondary aims were to identify barriers and to evaluate the effectiveness of national HPV vaccination campaigns over a six-year period in Singapore.We conducted and compared two cross-sectional surveys in 2013 and 2019 among female participants attending a general gynaecology clinic.A total of 597 participants completed the survey in 2013 and 2019. The participants were comparable in their race, marital status, educational level, occupation and monthly household income. Knowledge scores for cervical cancer and HPV infection showed significant improvement from 2013 to 2019. There was no significant difference in knowledge scores for HPV vaccination, which resulted in similar uptake of the HPV vaccine. Age, educational level and knowledge of HPV vaccine were significant predictors of acceptance of the HPV vaccine. The top two reasons for declining the HPV vaccine were the lack of knowledge and cost, as noted in the 2019 survey.The Singapore government's efforts to improve cervical cancer awareness through national campaigns and policy changes have led to an improvement in knowledge of HPV infection. However, this has not translated into improvements in the vaccine acceptance rates. The decision for vaccine uptake is complex, and there are multiple factors to be addressed to ensure cost-effective implementation of the strategies. Our study highlights the need for effective dissemination of vaccine information, additional subsidies and consideration of a mandatory school-based vaccination programme.