在一项由两个德国医疗中心进行的研究中,检查额外影像测试在低风险早期乳腺癌患者分期中的诊断性表现。
Diagnostic performance of additional imaging tests for staging purposes in a bicentric German series of low-risk early breast cancer patients.
发表日期:2023 Sep 07
作者:
Lisa Jung, Sarah Isabelle Huwer, Florin-Andrei Taran, Clara Unger, Carolin Müller, Erich-Franz Solomayer, Ingolf Juhasz-Böss, Jakob Neubauer
来源:
Bone & Joint Journal
摘要:
低风险早期乳腺癌很少会导致转移性疾病的发生,在这些患者中,是否需要进行额外的影像检查存在争议。我们的研究目的是在一组双中心德国低风险乳腺癌患者中评估常规分期程序。回顾性评估了2017年萨尔兰大学医院和弗莱堡大学医院诊断的所有早期低风险乳腺癌患者。评估了临床患者特征、额外影像检查次数和类型、随访检查及结果。分析了转移灶检出率和假阳性结果率。
共纳入203名患者,所有患者均接受了至少一项额外影像检查。最初进行了总计562次额外影像检查:166次胸部X线检查、169次上腹部超声检查、199次骨扫描、27次CT胸部和腹部检查,还有1次CT腹部检查。6.8%的患者报告了异常结果,需要进行38次额外影像检查。其中1名患者(0.5%)被发现骨转移。所进行的额外影像检查程序的假阳性结果率为6.6%。
在203名低风险早期乳腺癌患者中,仅有1名患者被发现有转移性疾病。总共进行了562次检查和38次随访检查,未检测到转移灶(平均每位患者约进行了3次检查)。额外影像检查的假阳性结果率为6.6%。需要对在低风险早期乳腺癌患者中进行额外影像检查以检测远处转移灶的效果进行重新评估。
© 2023. 本文作者。
Low-risk early breast cancer rarely leads to the development of metastatic disease, and in these patients, additional imaging test is controversial. The aim of our study was to evaluate the conventional staging procedures in a bicentric German series of low-risk breast carcinoma patients.Retrospective evaluation of all patients diagnosed with early, low-risk breast cancer at Saarland University Hospital and Freiburg University Hospital in 2017 was performed. Clinical patient characteristics, the number and type of additional imaging examinations, follow-up examinations, and results were evaluated. The detection rate of metastases and the rate of false-positive findings were analyzed.A total of 203 patients were included, with all patients received at least one additional imaging test. Initially, a total of 562 additional imaging examinations were performed: 166 chest X-rays, 169 upper abdominal ultrasounds, 199 bone scans, 27 computer tomographies (CT) chest and abdomen, and 1 CT abdomen. 6.8% of patients had abnormal findings reported, requiring 38 additional imaging examinations. One patient (0.5%) was found to have bone metastases. The rate of false-positive findings in the performed additional imaging procedures was 6.6%.Metastatic disease was detected in one of 203 patients with low-risk early breast cancer. A total of 562 examinations and additional 38 follow-up examinations were performed without detection of metastasis (this corresponds to approximately 3 examinations/patient). The rate of false-positive findings was 6.6%. The performance of additional imaging procedures for detection of distant metastases should be critically reconsidered in patients with low-risk early breast cancer.© 2023. The Author(s).