食品工业对姜黄素给予了很多关注，因为它具有潜在的生物活性特性。然而，由于其生物利用度低、稳定性差和水溶性问题，其应用受到严重限制。在本研究中，我们创建了以酪蛋白钠和羟甲基纤维素酸钠为载体的姜黄素纳米颗粒。通过扫描电子显微镜和透射电子显微镜的表征，荧光光谱、傅里叶变换红外光谱和X射线衍射研究表明，氢键、疏水作用和静电作用是纳米颗粒形成的主要驱动力。当酪蛋白钠与羟甲基纤维素酸钠的质量比为3:5时，SMCNPs显示出较小的粒径、更好的分散度和较高的包封率（粒径为166.8nm，多分散性指数为0.15，包封率为88.07%）。在体外模拟实验中，复合纳米颗粒表现出良好的抗氧化活性、物理稳定性和对肠道的持续释放作用，成功防止姜黄素过早释放进入胃液。最后，细胞毒性研究表明，制备的复合纳米颗粒具有良好的生物相容性，并可抑制肿瘤细胞（HT-29）的生长。总之，本研究中使用羟甲基纤维素酸钠和酪蛋白钠作为载体可能开辟了一种新的环保、持久的生物活性物质传递系统的途径。copyright © 2023. Elsevier B.V. 出版。

The food industry has paid lots of attentions to curcumin because of its potential bioactive qualities. However, its use is severely constrained by its low bioavailability, stability and water solubility. Herein, we created sodium caseinate and carboxymethylpachymaran (CMP) nanoparticles (SMCNPs) that were loaded with curcumin. The composite nanoparticles were spherical, as characterized by SEM and TEM, the fluorescence spectroscopy, FTIR and XRD research revealed that hydrogen bonding, hydrophobic interaction and electrostatic interaction were the main drivers behind the creation of the nanoparticles. The SMCNPs exhibited lower particle size, greater dispersion and higher encapsulation rate when the mass ratio of sodium caseinate to CMP was 3:5 (particle size of 166.8 nm, PDI of 0.15, and encapsulation efficiency of 88.07 %). The composite nanoparticles had good antioxidant activity, physical stability and sustained release effect on intestinal tract during the in vitro simulation experiments, successfully preventing the early release of curcumin into gastric fluid. Finally, cytotoxicity studies told that the prepared composite nanoparticles have good biocompatibility and can inhibit the growth of tumor cells (HT-29). In conclusion, using CMP and sodium caseinate as carriers in this study may open up a fresh, environmentally friendly, and long-lasting way to construct a bioactive material delivery system.Copyright © 2023. Published by Elsevier B.V.