CMTM6通过共调节PD-L1和CD58，实现了阴阳平衡以塑造抗肿瘤免疫。
PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity.
发表日期：2023 Aug 26
作者：
Hirohito Yamaguchi, Mien-Chie Hung
来源：
CANCER CELL
摘要：
CD58-CD2轴调控T细胞介导的肿瘤免疫，但CD58的调控机制尚不清楚。近期发表于《癌细胞》的两篇论文中，Miao等人和Ho等人阐明了CMTM6对CD58的调控机制，并展示了PD-L1与CD58之间意外的阴阳联系。版权所有© 2023 Elsevier Inc. 保留所有权利。
The CD58-CD2 axis regulates T cell-mediated cancer immunity, but little is known about the regulation of CD58. In two recent papers pubished in Cancer Cell, Miao et al. and Ho et al. define a mechanism of CD58 regulation by CMTM6 and show an unexpected yin-yang link between PD-L1 and CD58.Copyright © 2023 Elsevier Inc. All rights reserved.