在特定癌症患者群体中，利用冰片（IC）进行冷冻疗法是预防化疗引起的口腔粘膜炎（OM）的有效策略。然而，尽管有效，IC的使用可能会导致不良反应，例如恶心、麻木和牙齿射痛，这可能对医疗治疗产生不良影响。此外，IC需要优质水来最大程度地减小严重全身感染的风险。为了消除这些缺点，新型冷却装置作为替代冷却方法出现。因此，本研究的目的是评估额外口外冷却降低口内温度的疗效和耐受性。 本实验性试点研究在瑞典哥德堡大学撒尔格伦斯卡学院牙科研究所进行。总共招募了六名健康志愿者参与本研究。利用热成像相机测量基线、冷却30分钟和60分钟后的口腔黏膜温度，并完成与耐受性相关的问卷调查。 在冷却30分钟和60分钟后，口腔内温度分别降低了2.0摄氏度和2.3摄氏度。额外口外冷却耐受良好，所有受试者均能忍受完整的60分钟冷却过程。 额外口外冷却可以降低口腔黏膜温度，并且是一种耐受良好的冷却方法。 © 2023 BioMed Central Ltd.，Springer Nature的一部分。

Cryotherapy, using ice chips (IC) is an effective strategy to prevent chemotherapy-induced oral mucositis (OM) in selected cancer patient cohorts. However, although effective, use of IC may cause adverse reactions, e.g., nausea, numbness, and shooting pain in the teeth, which could have an adverse impact on the medical treatment. Furthermore, IC requires water of good quality to minimize risk of serious systemic infections. To eliminate these disadvantages, novel cooling devices have emerged as alternative cooling modalities. Thus, the aim was to evaluate the efficacy and tolerability profile of extraoral cooling for intraoral temperature reduction.This experimental pilot study was conducted at the Institute of Odontology, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. In total, six healthy volunteers were enrolled in this study. At baseline and following 30-, and 60 min of cooling with the extraoral cooling device, intraoral mucosal temperatures were measured using a thermographic camera, and a questionnaire related to tolerability was completed.Following 30-, and 60 min of cooling, the intraoral temperature decreased with 2.0 °C and 2.3 °C, respectively. Extraoral cooling was well tolerated, and all subjects endured the entire cooling session of 60 min.Extraoral cooling reduces intraoral mucosal temperatures and is a well-tolerated cooling modality.© 2023. BioMed Central Ltd., part of Springer Nature.