系统性炎症反应指数（SIRI）和全身免疫炎症指数（SII）已被引入作为炎症标志物，并预测癌症和心血管疾病的不良预后。在脊柱关节炎（SpA）中适当评估疾病活动可能具有挑战性。该研究的目的是评估细胞免疫炎症标志物和超声（US）评估斯蓉疾病活动的有用性。这项横断面研究涉及SpA患者（62例轴型SpA，38例外周型SpA，pSpA）。记录了患者的临床数据，包括压痛关节计数、肿胀关节计数、红细胞沉降率、C-反应蛋白、白细胞计数，并使用Bath强直性脊柱炎疾病活动指数（BASDAI）和银屑病关节炎疾病活动指数（DAPSA）评估疾病活动。计算了SIRI、SII、中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）以及淋巴细胞与单核细胞比率（LMR）。进行了超声检查（22个小关节、跟腱和足底筋膜以评估足底筋膜炎）。高疾病活动组（BASDAI > 4）的患者SII、SIRI、NLR和PLR值较高，而LMR值较低。中度/高度活动组的pSpA患者(DAPSA > 14)的SII值较高。SIRI与疾病活动的临床和实验室参数相关。SII与pSpA的超声参数相关。与外周关节的US活动和非活动相比，活动征象的患者SII和NLR值较高。与足底筋膜的US变化无关。该研究结果指出了SIRI和SII作为SpA患者疾病活动的生物标志物的价值。SII与外周关节的滑膜炎相关。

The systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII) have been introduced as inflammatory markers and predictors of poor prognosis in cancer and cardiovascular diseases. An appropriate evaluation of disease activity in spondyloarthritis (SpA) might be challenging. The purpose of this study was to evaluate the usefulness of cellular immune inflammation markers and ultrasound (US) evaluation of entheses and joints in the assessment of disease activity in SpA patients.This cross-sectional study involved patients with SpA (62 axial SpA, 38 peripheral SpA, pSpA). The clinical data of both tender, swollen joint counts, erythrocyte sedimentation rate, C-reactive protein, white blood cell counts, and disease activity using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Disease Activity Index for Psoriatic Arthritis (DAPSA), were recorded. The SIRI, SII, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were calculated. US examination was performed (22 small joints, Achilles tendon, and plantar aponeurosis for enthesitis).The SII, SIRI, NLR, and PLR were higher, and LMR was lower in patients with high disease activity (BASDAI > 4). Higher SII was observed in pSpA patients with moderate/high disease activity (DAPSA > 14). The SIRI was correlated with clinical and laboratory parameters of disease activity. The SII was correlated with US parameters in pSpA. Higher SII and NLR values were found in patients with signs of activity compared with no activity in the US of peripheral joints. There were no associations with US changes in entheses.The results of this study point to the value of SIRI and SII as biomarkers of disease activity in patients with SpA. The SII was associated with synovitis in the US of the peripheral joints.