存在越来越多的证据表明，由于常用化合物的制造和加工过程中引入的内分泌干扰物（EDs）可以改变激素信号和功能。由于它们的半衰期和持久性较长，EDs通常不仅出现在工业产品中，而且还存在于家庭和环境中，为长期暴露创造了条件。聚溴联苯醚（PBDEs）是常用的EDs，用于工业产品，如阻燃剂，并且最近的研究越来越多地显示它们可能干扰代谢和致癌途径。在本文中，意大利医学糖尿病协会（AMD）、意大利糖尿病学社会（SID）、意大利医学肿瘤学协会（AIOM）、意大利内分泌学协会（SIE）和意大利药理学协会（SIF）的多学科专家小组提供了对PBDEs在人类健康和疾病中潜在作用的综述，探讨了分子和临床方面，并侧重于代谢和致癌途径。

There is increasing evidence of the role of endocrine disruptors (EDs) derived from commonly employed compounds for manufacturing and processing in altering hormonal signaling and function. Due to their prolonged half-life and persistence, EDs can usually be found not only in industrial products but also in households and in the environment, creating the premises for long-lasting exposure. Polybrominated diphenyl ethers (PBDEs) are common EDs used in industrial products such as flame retardants, and recent studies are increasingly showing that they may interfere with both metabolic and oncogenic pathways. In this article, a multidisciplinary panel of experts of the Italian Association of Medical Diabetologists (AMD), the Italian Society of Diabetology (SID), the Italian Association of Medical Oncology (AIOM), the Italian Society of Endocrinology (SIE) and the Italian Society of Pharmacology (SIF) provides a review on the potential role of PBDEs in human health and disease, exploring both molecular and clinical aspects and focusing on metabolic and oncogenic pathways.