头颈肿瘤复放射治疗综述:到目前为止实现了什么?
An Overview of Head and Neck Tumor Reirradiation: What Has Been Achieved So Far?
发表日期:2023 Sep 04
作者:
Konstantin Gordon, Daniil Smyk, Igor Gulidov, Kirill Golubev, Timur Fatkhudinov
来源:
Cancers
摘要:
头颈部癌症(HNCs)治疗后的复发率可能达到70%,大多数情况下报道预后不良。对于复发HNCs的治愈方案主要取决于治疗史和复发肿瘤的定位。对于HNCs的重复照射是有效的,并已被纳入大多数指南。然而,由于快速重复区内复发的严重毒性发生率高,该选项仍然具有临床挑战性。放射治疗(RT)的最新技术进展为升级重复照射方案提供了手段。尽管大多数医院仍专注于传统和广泛可用的调节型RT,但粒子疗法选项逐渐成为耐受性较好并为复发HNCs提供进一步治疗机会。然而,数据的高异质性和缺乏大规模前瞻性研究阻碍了这一进展。本综述旨在总结临床角度下HNCs重复照射的结果。
The recurrence rate of head and neck cancers (HNCs) after initial treatment may reach 70%, and poor prognosis is reported in most cases. Curative options for recurrent HNCs mainly depend on the treatment history and the recurrent tumor localization. Reirradiation for HNCs is effective and has been included in most guidelines. However, the option remains clinically challenging due to high incidence of severe toxicity, especially in cases of quick infield recurrence. Recent technical advances in radiation therapy (RT) provide the means for upgrade in reirradiation protocols. While the majority of hospitals stay focused on conventional and widely accessible modulated RTs, the particle therapy options emerge as tolerable and providing further treatment opportunities for recurrent HNCs. Still, the progress is impeded by high heterogeneity of the data and the lack of large-scale prospective studies. This review aimed to summarize the outcomes of reirradiation for HNCs in the clinical perspective.