骨形成蛋白7（BMP7）是一种属于转化生长因子-β（TGF- β）超家族的细胞外信号蛋白。以往的转录组数据表明，在卵巢癌中BMP7表达可能出现紊乱，并可能在疾病的侵袭性中发挥重要作用。然而，目前尚未对患者肿瘤中的蛋白表达进行充分研究。本研究旨在评估575例卵巢癌患者肿瘤样本中BMP7蛋白的表达，并建立其与不同临床终点的关联。使用了575例接受不同亚型卵巢癌手术的患者的卵巢癌组织样本。利用免疫组织化学技术和组织微阵列和全面肿瘤切片对BMP7蛋白表达进行了分析。高表达BMP7与侵袭性卵巢癌临床病理学变量显著关联，包括FIGO期、高分级、残留病和不良总生存。细胞质和细胞核BMP7的增加表达与FIGO期进展、肿瘤高分级、残余肿瘤和高级别浆液性癌症显著关联（分别为p = 0.001、0.005、0.004、<0.001和p < 0.001、<0.001、0.002、0.001）。增加的细胞质和细胞核BMP7表达也与不良总生存显著相关（分别为p = 0.001和0.046）。该研究突显了BMP7作为预后工具和作为限制卵巢癌疾病进展的潜在新靶点的潜力。© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.

Bone Morphogenetic Protein 7 (BMP7) is an extracellular signalling protein that belongs to the transforming growth factor-β (TGF- β) superfamily. Previous transcriptomic data suggested that BMP7 expression may be disrupted in ovarian carcinoma and may play an important role in the aggressiveness of the disease. However, the protein expression in patient tumours has not been well studied. The current study aimed to assess BMP7 protein expression in a large cohort of ovarian carcinoma patient tumour samples to establish its associations with different clinical endpoints. Ovarian carcinoma tissue samples from 575 patients who underwent surgery for different subtypes of ovarian cancer were used. BMP7 protein expression was analysed by immunohistochemistry using tissue microarray and full face tumour sections. High BMP7 expression is associated with aggressive ovarian cancer clinicopathological variables including advanced FIGO stage, high grade, residual disease and poor overall survival. Elevated cytoplasmic and nuclear BMP7 expression was significantly associated with advanced FIGO stage, high tumour grade, presence of residual tumours and high-grade serous carcinomas (p = 0.001, 0.005, 0.004, <0.001 and p < 0.001, <0.001, 0.002, 0.001 respectively). Increased cytoplasmic and nuclear BMP7 expression was also significantly associated with an adverse overall survival (p = 0.001 and 0.046 respectively). The study highlights the potential of BMP7 as a prognostic tool and as a potential novel target for ovarian cancer therapies to limit disease progression.© 2023 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.