肿瘤相关巨噬细胞构成肿瘤微环境中的主要细胞种群，发挥调控微环境组成的重要作用。新出现的证据表明代谢配置决定了肿瘤相关巨噬细胞的表型。肿瘤相关巨噬细胞的功能高度依赖葡萄糖代谢，糖酵解是主要的代谢途径。近期的报道表明肿瘤相关巨噬细胞的葡萄糖通量多样且与癌细胞之间存在复杂物质通讯。然而，肿瘤相关巨噬细胞中葡萄糖通量如何与糖酵解相连接以影响肿瘤进展和肿瘤微环境仍不明确。此外，尽管单细胞测序技术的发展使得能够更清晰准确地对肿瘤相关巨噬细胞进行分类，但从单细胞组学角度总结肿瘤相关巨噬细胞的代谢配置尚未得到很好的概括。在这里，我们回顾了关于肿瘤相关巨噬细胞葡萄糖代谢的现有知识，并从单细胞组学的视角总结了不同肿瘤相关巨噬细胞亚型的代谢配置。另外，本文还描述了当前针对肿瘤相关巨噬细胞的糖酵解靶向策略在癌症治疗中的应用。© 2023 UICC.

Tumor-associated macrophages constitute the main cell population in the tumor microenvironment and play a crucial role in regulating the microenvironment composition. Emerging evidence has revealed that the metabolic profile determines the tumor-associated macrophage phenotype. Tumor-associated macrophage function is highly dependent on glucose metabolism, with glycolysis being the major metabolic pathway. Recent reports have demonstrated diversity in glucose flux of tumor-associated macrophages and complex substance communication with cancer cells. However, how the glucose flux in tumor-associated macrophages connects with glycolysis to influence tumor progression and the tumor microenvironment is still obscure. Moreover, while the development of single-cell sequencing technology allows a clearer and more accurate classification of tumor-associated macrophages, the metabolic profiles of tumor-associated macrophages from the perspective of single-cell omics has not been well summarized. Here, we review the current state of knowledge on glucose metabolism in tumor-associated macrophages and summarize the metabolic profiles of different tumor-associated macrophage subtypes from the perspective of single-cell omics. Additionally, we describe the current strategies targeting glycolysis in tumor-associated macrophages for cancer therapy.© 2023 UICC.