通过细胞块上免疫细胞化学和下一代测序确定胸腔积液中间质软骨肉瘤的HEY1::NCOA2融合。
Detection of mesenchymal chondrosarcoma in pleural effusion with immunocytochemistry and determination of HEY1::NCOA2 fusion by next-generation sequencing on cell block.
发表日期：2023 Sep 09
作者：
Jingmin Zhong, Qingjie Wang, Yilin Xie, Zhaorong Niu, Diwei Zhou
来源：
Cellular & Molecular Immunology
摘要：
间叶性软骨肉瘤（MC）是一种罕见但极具侵袭性的软骨肉瘤，其特点是既存在原始的间叶细胞，又存在完全发育的软骨组织。通过在胸腔积液中发现双相形态并使用下一代测序检测HEY1::NCOA2融合基因，可以作为准确诊断的重要指标。© 2023 John Wiley & Sons Ltd.
Mesenchymal chondrosarcoma (MC) is a rare but extremely aggressive type of chondrosarcoma distinguished by the presence of both primitive mesenchymal cells and fully developed chondroid tissue. The identification of a biphasic morphology in pleural effusion, along with detection of the HEY1::NCOA2 fusion using next-generation sequencing, serve as vital indicators for an accurate diagnosis.© 2023 John Wiley & Sons Ltd.