铅卤化物钙钛矿（LHPs）是下一代光电材料的优秀候选者，具有广阔的应用和商业价值前景。然而，关于其毒性的了解很少，这可能限制了它们的商业化。在本研究中，我们首次研究了具有代表性的CsPbBr3纳米颗粒在LHPs中的心脏毒性和分子机制。通过将CsPbBr3纳米颗粒经鼻腔给予癌症研究所（ICR）小鼠，并借助先进的同步辐射、质谱和超声成像技术，我们发现CsPbBr3纳米颗粒可以通过在心肌组织中积累严重影响心肌收缩功能。RNA测序和Western印迹证明，CsPbBr3纳米颗粒诱导心肌细胞产生过度氧化应激，从而引发内质网应激，干扰钙离子平衡，最终导致细胞凋亡。我们的研究结果凸显了LHPs的心脏毒性作用，并为产品提供了重要的毒理学数据。

Lead halide perovskites (LHPs) are outstanding candidates for next-generation optoelectronic materials, with considerable prospects of use and commercial value. However, knowledge about their toxicity is scarce, which may limit their commercialization. Here, for the first time, we studied the cardiotoxicity and molecular mechanisms of representative CsPbBr3 nanoparticles in LHPs. After their intranasal administration to Institute of Cancer Research (ICR) mice, using advanced synchrotron radiation, mass spectrometry, and ultrasound imaging, we revealed that CsPbBr3 nanoparticles can severely affect cardiac systolic function by accumulating in the myocardial tissue. RNA sequencing and Western blotting demonstrated that CsPbBr3 nanoparticles induced excessive oxidative stress in cardiomyocytes, thereby provoking endoplasmic reticulum stress, disturbing calcium homeostasis, and ultimately leading to apoptosis. Our findings highlight the cardiotoxic effects of LHPs and provide crucial toxicological data for the product.