受体相互作用蛋白激酶（RIPK）是一类参与各种应激信号整合的丝氨酸/苏氨酸激酶。在对多种细胞外或细胞内刺激做出反应时，RIP激酶参与信号级联使得NF-κB和丝裂原激活蛋白激酶的激活，细胞死亡，炎症，分化以及Wnt信号，并且能够具有激酶依赖和激酶非依赖的功能。虽然之前曾推测RIPK家族包括7种成员，但系统发育分析表明只有5种是真正的RIPK。RIPK1和RIPK3主要参与控制和执行角质形成细胞的坏死程序，而RIPK4控制角质形成细胞的增殖和分化，从而在皮肤中充当肿瘤抑制因子。因此，在本综述中，我们总结和讨论了RIPK在皮肤稳态以及相关信号通路中的功能。© 2023. 作者。

The receptor interacting protein kinases (RIPK) are a family of serine/threonine kinases that are involved in the integration of various stress signals. In response to several extracellular and/or intracellular stimuli, RIP kinases engage signaling cascades leading to the activation of NF-κB and mitogen-activated protein kinases, cell death, inflammation, differentiation and Wnt signaling and can have kinase-dependent and kinase-independent functions. Although it was previously suggested that seven RIPKs are part of the RIPK family, phylogenetic analysis indicates that there are only five genuine RIPKs. RIPK1 and RIPK3 are mainly involved in controlling and executing necroptosis in keratinocytes, while RIPK4 controls proliferation and differentiation of keratinocytes and thereby can act as a tumor suppressor in skin. Therefore, in this review we summarize and discuss the functions of RIPKs in skin homeostasis as well as the signaling pathways involved.© 2023. The Author(s).