隐性嵌入在他们的母蛋白中的生物活性肽的一个亚科叫作隐性肽，具备多种生物学功能。阳离子隐性肽可以作为现代药物应用于传染病和癌症领域，因为它们的作用机制不太可能受到被治疗细胞中的基因突变的影响，因此解决了这两个领域当前的未满足需求。在本综述中，我们介绍隐性肽的最新认识，使用可用的在线数据库和预测工具可持续地开采隐性肽的方法，特别关注其抗微生物和抗癌潜力，以及其在临床设置中的潜在应用。版权所有 © 2023 Elsevier Ltd. 保留所有权利。

Cryptides are a subfamily of bioactive peptides embedded latently in their parent proteins and have multiple biological functions. Cationic cryptides could be used as modern drugs in both infectious diseases and cancers because their mechanism of action is less likely to be affected by genetic mutations in the treated cells, therefore addressing a current unmet need in these two areas of medicine. In this review, we present the current understanding of cryptides, methods to mine them sustainably using available online databases and prediction tools, with a particular focus on their antimicrobial and anticancer potential, and their potential applicability in a clinical setting.Copyright © 2023 Elsevier Ltd. All rights reserved.