研究动态
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山楂属多糖的制备、结构表征、生物活性及应用:一篇综述。

Preparation, structural characterization, bioactivities, and applications of Crataegus spp. polysaccharides: A review.

发表日期:2023 Sep 07
作者: Lei Cheng, Qiuli Yang, Chaohai Li, Jiamei Zheng, Yaping Wang, Baozhong Duan
来源: ANTIOXIDANTS & REDOX SIGNALING

摘要:

山楂属于蔷薇科。由于其丰富的生物活性化合物,山楂被认为是一种具有药用和食用价值的有益植物,因而被赋予“营养水果”的称号。多糖是由糖苷键连接的碳水化合物聚合体,是山楂多种重要的生物活性成分之一。最近,山楂多糖(CPs)因其多样化的生物活性引起了广泛关注,包括益生元、降脂、抗癌、抗菌、抗氧化和免疫生物学特性等。在这里,我们提供了关于CPs的最新研究的综述。分析结果显示,CPs表现出广泛的分子量分布,从5.70 Da到4.76 × 10^8 Da不等,并由甘露糖、鼠李糖和阿拉伯糖等多种单糖组成。结构-活性关系研究表明,CPs的生物功能与其分子量、半乳糖酸含量和化学修饰密切相关。此外,CPs具有优异的生物利用度、生物相容性和生物降解性,使其成为食品、药物和化妆品行业应用的有前景的候选物质。本文还审视了CPs的潜在发展和未来研究方向。总的来说,本文为将CPs作为治疗剂和多功能食品添加剂进行未来研究和开发提供了全面的知识和基础。版权所有 ©2023 Elsevier B.V. 发布。
Crataegus, is a genus within the Rosaceae family. It is recognized as a valuable plant with both medicinal and edible qualities, earning it the epithet of the "nutritious fruit" owing to its abundant bioactive compounds. Polysaccharides are carbohydrate polymers linked by glycosidic bonds, one of the crucial bioactive ingredients of Crataegus spp. Recently, Crataegus spp. polysaccharides (CPs) have garnered considerable attention due to their diverse range of bioactivities, including prebiotic, hypolipidemic, anticancer, antibacterial, antioxidant, and immunobiological properties. Herein, we provide a comprehensive overview of recent research on CPs. The analysis revealed that CPs exhibited a broad molecular weight distribution, ranging from 5.70 Da to 4.76 × 108 Da, and are composed of various monosaccharide constituents such as mannose, rhamnose, and arabinose. Structure-activity relationships demonstrated that the biological function of CPs is closely associated with their molecular weight, galacturonic acid content, and chemical modifications. Additionally, CPs have excellent bioavailability, biocompatibility, and biodegradability, which make them promising candidates for applications in the food, medicine, and cosmetic industries. The article also scrutinized the potential development and future research directions of CPs. Overall, this article provides comprehensive knowledge and underpinnings of CPs for future research and development as therapeutic agents and multifunctional food additives.Copyright © 2023. Published by Elsevier B.V.