淋巴细胞与单核细胞比值（LMR）已被证明是胃癌预后的有效预测指标。然而，对于粘液腺癌胃癌的预测准确性目前尚不清楚。本研究旨在评估术前LMR对粘液腺癌胃癌的预后准确性。研究纳入了2012年1月至2016年12月间就诊于中南大学湘雅医院消化道外科的212例粘液腺癌胃癌患者。通过受试者工作特征曲线下的面积探究术前LMR的预后预测准确性。利用单因素分析确定影响患者生存的显著因素，并通过多因素分析鉴定与粘液腺癌胃癌独立相关的因素。单因素分析结果显示，粘液腺癌胃癌患者的生存与多个因素强相关，包括肿瘤侵袭（χ2 = 49.726，P < 0.001）、淋巴结转移（χ2 = 30.269，P < 0.001）、pTNM分期（χ2 = 49.322，P < 0.001）、手术方式（χ2 = 8.489，P = 0.004）、年龄（t = -2.213，P < 0.028）、癌胚抗原（CEA）（Z = -3.265，P = 0.001）、血小板淋巴细胞比值（Z = -2.196，P = 0.028）、LMR（Z = -2.226，P = 0.026）、白蛋白（ALB）（t = 3.284，P = 0.001）、预后营养指数（t = -3.789，P < 0.001）以及纤维蛋白（FIB）（Z = -3.065，P = 0.002）。此外，多因素分析进一步证实，年龄（HR：0.563，95%CI：0.363-0.873）、肿瘤侵袭深度（HR：0.226，95%CI：0.098-0.520）、pTNM分期（HR：0.444，95%CI：0.255-0.771）、术前CEA水平（HR：0.597，95%CI：0.386-8.790）及术前LMR水平（HR：1.776，95%CI：1.150-2.741）是影响粘液腺癌胃癌预后的独立因素。在粘液腺癌胃癌患者中，术前LMR水平低预示着不良预后。低LMR组与高LMR组的死亡风险比为1.776。©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

The ratio of lymphocytes to monocytes (LMR) has been shown to be an effective predictor of gastric cancer prognosis. However, its predictive accuracy for signet ring gastric cancer is currently not well understood.To evaluate the prognosis predictive accuracy of preoperative LMR in signet ring gastric cancer.A total of 212 signet ring gastric cancer patients admitted at the Xiangya Hospital of Central South University, Department of Gastrointestinal Surgery, from January 2012 to December 2016 were enrolled in the study. The prognosis predictive accuracy of preoperative LMR was explored based on the area under the receiver operating characteristic. Factors that significantly affect the survival of patients were identified using single factor analysis, and those that were independently associated with signet ring gastric cancer were identified through multivariate analysis.The results of the single factor analysis revealed a strong correlation between the survival of signet ring gastric cancer patients and several factors, including tumor invasion (χ2 = 49.726; P < 0.001), lymph node metastasis (χ2 = 30.269; P < 0.001), pTNM stage (χ2 = 49.322; P < 0.001), surgical approach (χ2 = 8.489; P = 0.004), age (t = -2.213; P < 0.028), carcinoembryonic antigen (CEA) (Z = -3.265; P = 0.001), platelet-to-lymphocyte ratio (Z = -2.196; P = 0.028), LMR (Z = -2.226; P = 0.026), ALB (t = 3.284; P = 0.001), prognostic nutritional index (t = -3.789; P < 0.001) and FIB (Z = -3.065; P = 0.002). Furthermore, the multivariate analysis further demonstrated that age (HR: 0.563, 95%CI: 0.363-0.873), tumor invasion depth (HR: 0.226, 95%CI: 0.098-0.520), pTNM stage (HR: 0.444, 95%CI: 0.255-0.771), preoperative CEA level (HR: 0.597, 95%CI: 0.386-8.790), and preoperative LMR level (HR: 1.776, 95%CI: 1.150-2.741) were independent factors influencing the prognosis of signet ring gastric cancer.In signet ring gastric cancer patients, a low preoperative LMR level predicts poor prognosis. The death risk ratio of the low LMR group compared to the high LMR group is 1.776.©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.