放松警惕：cAMP 激活剂可以改善 GBM 的免疫治疗。
Let the Guard Down: cAMP Activators Can Improve Immunotherapy in GBM.
发表日期：2023 Oct 04
作者：
Juyeun Lee, Kristen E Kay, Michael A Vogelbaum, Justin D Lathia
来源：
Cancer Immunology Research
摘要：
增强 T 细胞对胶质母细胞瘤 (GBM) 肿瘤的浸润已被证明具有挑战性，但对于提高这种致命癌症患者的免疫治疗效果仍然至关重要。在本期中，Qin、Huang、Li 及其同事发现，抑制癌症干细胞驱动的血管形成是增强 GBM 免疫治疗的一个有希望的靶点。参见Qin、Huang、Li 等人的相关文章，第17 页。 1351 (2).©2023 美国癌症研究协会。
Enhancing T-cell infiltration into glioblastoma (GBM) tumors has proven challenging yet remains crucial for improving the efficacy of immunotherapy for patients with this deadly cancer. In this issue, Qin, Huang, Li, and colleagues find that inhibiting vasculature formation driven by cancer stem cells is a promising target to enhance immunotherapy in GBM. See related article by Qin, Huang, Li, et al., p. 1351 (2).©2023 American Association for Cancer Research.