TOX基因在结直肠癌中的表观遗传干细胞维持和化疗抗性通路
A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer.
发表日期：2023 Sep
作者：
Christopher G Hubert, Shaun R Stauffer, Justin D Lathia
来源：
Epigenetics & Chromatin
摘要：
癌干细胞通过自我更新和对治疗的抵抗驱动肿瘤的生长和存活，但上游机制尚未明确。《PLOS Biology》的一项结肠癌研究揭示了一个新的信号网络，将表观遗传调控与这些表型联系起来。版权：©2023 Hubert et al. 本文是根据知识共享署名许可证的开源文章，在原作者和来源被列入信用的情况下，允许在任何媒体中自由使用、分发和再生产。
Cancer stem cells drive tumor growth and survival via self-renewal and therapeutic resistance, but the upstream mechanisms are not well defined. In this issue of PLOS Biology, a study in colon cancer reveals a new signalling network that links epigenetic regulation to these phenotypes.Copyright: © 2023 Hubert et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.